Relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in patients with type 2 diabetes mellitus

The possible occurrence of increased non-enzymatic glycosylation of serum insulin-like growth factor binding protein-3 (IGFBP-3) in vivo and the changes that would simultaneously occur in serum levels of IGFBP-3 and insulin-like growth factor-1 (IGF-I) were investigated. We measured levels of IGF-I...

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Autores principales: Cortizo, Ana María, Lee, P. D. K., Cédola, Norberto V., Jasper, H., Gagliardino, Juan José
Formato: Articulo
Lenguaje:Inglés
Publicado: 1998
Materias:
Ciencias Médicas
Diabetes Mellitus Tipo 2
non-enzymatic glycosylation, insulin-like growth factor, binding proteins, chronic complications, diabetes mellitus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/76262
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-76262
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Diabetes Mellitus Tipo 2
non-enzymatic glycosylation, insulin-like growth factor, binding proteins, chronic complications, diabetes mellitus
spellingShingle Ciencias Médicas
Diabetes Mellitus Tipo 2
non-enzymatic glycosylation, insulin-like growth factor, binding proteins, chronic complications, diabetes mellitus
Cortizo, Ana María
Lee, P. D. K.
Cédola, Norberto V.
Jasper, H.
Gagliardino, Juan José
Relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in patients with type 2 diabetes mellitus
topic_facet Ciencias Médicas
Diabetes Mellitus Tipo 2
non-enzymatic glycosylation, insulin-like growth factor, binding proteins, chronic complications, diabetes mellitus
description The possible occurrence of increased non-enzymatic glycosylation of serum insulin-like growth factor binding protein-3 (IGFBP-3) in vivo and the changes that would simultaneously occur in serum levels of IGFBP-3 and insulin-like growth factor-1 (IGF-I) were investigated. We measured levels of IGF-I and IGFBP-3 and the degree of glycation of total serum protein and IGFBP-3, in serum samples obtained from patients with poorly controlled non-insulin-dependent diabetes (type 2) and from age-matched non-diabetic controls. Type 2 diabetic patients had significantly higher glycated serum protein (GlyP) levels. GlyP significantly correlated with age in the control (r = 0.315, P<0.05) but not in the type 2 diabetes group. Control and diabetic subjects had comparable serum IGF-I levels and in both groups IGF-I levels tended to decrease with age (r = -0.567, P<0.001 and r = -0.465, P<0.05 for control and type 2 diabetic subjects, respectively). In the type 2 diabetes group, IGF-I levels showed a negative correlation with serum GlyP values (r = -0.476, P<0.05). Type 2 diabetic and control patients had comparable serum IGFBP-3 levels, which were significantly higher in diabetic patients in the older age subgroups. A negative correlation was found between IGFBP-3 levels and age in the control (r = -0.705, P<0.001) and in the type 2 diabetes groups (r = -0.463, P<0.05). A significant negative correlation was found between IGFBP-3 levels and GlyP in control (r = -0.449, P<0.002) but not in type 2 diabetic subjects. The mean glycated IGFBP-3 (GlyIGFBP-3) levels were higher in the oldest type 2 diabetic patients. In these patients, GlyIGFBP-3 was negatively associated with IGF-I levels (r = -0.447, P<0.05). The IGF-I/IGFBP-3 molar ratio was significantly reduced in the 46-60-year-old type 2 diabetic group, whereas the IGF-I/IGFBP-3 ratio was positively and significantly correlated with GlyP levels only in the control group (r = 0.489, P<0.01). Our results show that: a) increased non-enzymatic glycosylation of IGFBP-3 occurs in vivo; and b) this effect is accompanied by an increase in IGFBP-3 levels. These results suggest that the IGF-I/IGFBP-3 system is another target for the metabolic derangements of type 2 diabetes. Its alterations might play a role in diabetic complications.
format Articulo
Articulo
author Cortizo, Ana María
Lee, P. D. K.
Cédola, Norberto V.
Jasper, H.
Gagliardino, Juan José
author_facet Cortizo, Ana María
Lee, P. D. K.
Cédola, Norberto V.
Jasper, H.
Gagliardino, Juan José
author_sort Cortizo, Ana María
title Relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in patients with type 2 diabetes mellitus
title_short Relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in patients with type 2 diabetes mellitus
title_full Relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in patients with type 2 diabetes mellitus
title_fullStr Relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in patients with type 2 diabetes mellitus
title_full_unstemmed Relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in patients with type 2 diabetes mellitus
title_sort relationship between non-enzymatic glycosylation and changes in serum insulin-like growth factor-1 (igf-1) and igf-binding protein-3 levels in patients with type 2 diabetes mellitus
publishDate 1998
url http://sedici.unlp.edu.ar/handle/10915/76262
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