Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction

We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers...

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Detalles Bibliográficos
Autores principales: Villagarcía, Hernán Gonzalo, Sabugo, Vanesa, Castro, María Cecilia, Schinella, Guillermo Raúl, Castrogiovanni, Daniel, Spinedi, Eduardo, Massa, María Laura, Francini, Flavio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Médicas
Glucocorticoides
Estrés Oxidativo
Hígado
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/75623
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-75623
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Glucocorticoides
Estrés Oxidativo
Hígado
spellingShingle Ciencias Médicas
Glucocorticoides
Estrés Oxidativo
Hígado
Villagarcía, Hernán Gonzalo
Sabugo, Vanesa
Castro, María Cecilia
Schinella, Guillermo Raúl
Castrogiovanni, Daniel
Spinedi, Eduardo
Massa, María Laura
Francini, Flavio
Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
topic_facet Ciencias Médicas
Glucocorticoides
Estrés Oxidativo
Hígado
description We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs)were increased. In conclusion adultMSGrats developed an insulinresistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis.These features, shared by both metabolic and Cushing’s syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis. Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation.
format Articulo
Articulo
author Villagarcía, Hernán Gonzalo
Sabugo, Vanesa
Castro, María Cecilia
Schinella, Guillermo Raúl
Castrogiovanni, Daniel
Spinedi, Eduardo
Massa, María Laura
Francini, Flavio
author_facet Villagarcía, Hernán Gonzalo
Sabugo, Vanesa
Castro, María Cecilia
Schinella, Guillermo Raúl
Castrogiovanni, Daniel
Spinedi, Eduardo
Massa, María Laura
Francini, Flavio
author_sort Villagarcía, Hernán Gonzalo
title Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
title_short Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
title_full Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
title_fullStr Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
title_full_unstemmed Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
title_sort chronic glucocorticoid-rich milieu and liver dysfunction
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/75623
work_keys_str_mv AT villagarciahernangonzalo chronicglucocorticoidrichmilieuandliverdysfunction
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bdutipo_str Repositorios
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