Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release

Ions released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on me...

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Detalles Bibliográficos
Autores principales: Cortizo, María Cecilia, Fernández Lorenzo de Mele, Mónica Alicia, Cortizo, Ana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2004
Materias:
Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/71077
https://digital.cic.gba.gob.ar/handle/11746/4513
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-71077
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales
spellingShingle Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales
Cortizo, María Cecilia
Fernández Lorenzo de Mele, Mónica Alicia
Cortizo, Ana María
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
topic_facet Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales
description Ions released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media.
format Articulo
Articulo
author Cortizo, María Cecilia
Fernández Lorenzo de Mele, Mónica Alicia
Cortizo, Ana María
author_facet Cortizo, María Cecilia
Fernández Lorenzo de Mele, Mónica Alicia
Cortizo, Ana María
author_sort Cortizo, María Cecilia
title Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_short Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_full Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_fullStr Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_full_unstemmed Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_sort metallic dental material biocompatibility in osteoblastlike cells : correlation with metal ion release
publishDate 2004
url http://sedici.unlp.edu.ar/handle/10915/71077
https://digital.cic.gba.gob.ar/handle/11746/4513
work_keys_str_mv AT cortizomariacecilia metallicdentalmaterialbiocompatibilityinosteoblastlikecellscorrelationwithmetalionrelease
AT fernandezlorenzodemelemonicaalicia metallicdentalmaterialbiocompatibilityinosteoblastlikecellscorrelationwithmetalionrelease
AT cortizoanamaria metallicdentalmaterialbiocompatibilityinosteoblastlikecellscorrelationwithmetalionrelease
bdutipo_str Repositorios
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