Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet

The intake of a fructose-rich diet (FRD) in the normal female rat induces features similar to those observed in the human metabolic syndrome phenotype. We studied the impact of FRD administration to mothers on pregnancy outcome. On gestational day (Gd) zero rats were assigned to either group: ad lib...

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Autores principales: Alzamendi, Ana, Del Zotto, Héctor Herminio, Castrogiovanni, Daniel, Romero, José, Giovambattista, Andrés, Spinedi, Eduardo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Médicas
Fructosa
Insulina
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/67015
https://www.hindawi.com/journals/isrn/2012/757913/
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-67015
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Fructosa
Insulina
spellingShingle Ciencias Médicas
Fructosa
Insulina
Alzamendi, Ana
Del Zotto, Héctor Herminio
Castrogiovanni, Daniel
Romero, José
Giovambattista, Andrés
Spinedi, Eduardo
Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet
topic_facet Ciencias Médicas
Fructosa
Insulina
description The intake of a fructose-rich diet (FRD) in the normal female rat induces features similar to those observed in the human metabolic syndrome phenotype. We studied the impact of FRD administration to mothers on pregnancy outcome. On gestational day (Gd) zero rats were assigned to either group: ad libitum drinking tap water alone (normal diet, ND) or containing fructose (10% w/vol; FRD) through pregnancy; all rats were fed a Purina chow diet ad libitum ND and FRD rats were daily cotreated or not with metformin (60 mg/Kg/day oral; ND + MF and FRD + MF) and submitted to a high glucose load test on Gd 14. Additionally, placentas from different groups were studied on Gd 20. Data indicated that: (1) although FRD rats well tolerated glucose overload, their circulating levels of insulin were significantly higher than in ND rats; (2) the mesometrial triangle blood vessel area was significantly lower in placentas from FRD than ND dams; (3) the detrimental effects of FRD administration to mothers were ameliorated by metformin cotreatment. Our study suggests that excessive intake of fructose during pregnancy enhanced the risk for developing gestational diabetes and subsequent preeclampsia, and that metformin prevented the poor pregnancy outcome induced by FRD.
format Articulo
Articulo
author Alzamendi, Ana
Del Zotto, Héctor Herminio
Castrogiovanni, Daniel
Romero, José
Giovambattista, Andrés
Spinedi, Eduardo
author_facet Alzamendi, Ana
Del Zotto, Héctor Herminio
Castrogiovanni, Daniel
Romero, José
Giovambattista, Andrés
Spinedi, Eduardo
author_sort Alzamendi, Ana
title Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet
title_short Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet
title_full Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet
title_fullStr Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet
title_full_unstemmed Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet
title_sort oral metformin treatment prevents enhanced insulin demand and placental dysfunction in the pregnant rat fed a fructose-rich diet
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/67015
https://www.hindawi.com/journals/isrn/2012/757913/
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