Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder which manifests as a motor disorder, characterized by slowness of movements, rigidity and tremor. Motor dysfunction of PD is due to dopamine loss in the neostriatum and due to the neurodegeneration of dopaminergic neuron’s cell bod...

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Detalles Bibliográficos
Autor principal: Rodríguez, Gaspar
Otros Autores: Bellini, María José
Formato: Tesis Tesis de grado
Lenguaje:Español
Publicado: 2017
Materias:
Biología
IGF-1
Enfermedad de Parkinson
Enfermedades Neurodegenerativas
alfa-Sinucleína
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/64897
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-64897
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Biología
IGF-1
Enfermedad de Parkinson
Enfermedades Neurodegenerativas
alfa-Sinucleína
spellingShingle Biología
IGF-1
Enfermedad de Parkinson
Enfermedades Neurodegenerativas
alfa-Sinucleína
Rodríguez, Gaspar
Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
topic_facet Biología
IGF-1
Enfermedad de Parkinson
Enfermedades Neurodegenerativas
alfa-Sinucleína
description Parkinson’s Disease (PD) is a progressive neurodegenerative disorder which manifests as a motor disorder, characterized by slowness of movements, rigidity and tremor. Motor dysfunction of PD is due to dopamine loss in the neostriatum and due to the neurodegeneration of dopaminergic neuron’s cell bodies of the Substantia Nigra Pars Compacta (SNPC). Evidence suggests that chronic neuroinflammation, mediated by activated microglial and astroglial cells in the SNPC, could be essential for the degenerative process. It is well known that IGF1 plays a key role in neuroprotection in physiological conditions, both in health and disease. Previous studies of our group have shown that Rad-IGF ICV gene therapy had a restorative effect on motor skills of aged rats.
author2 Bellini, María José
author_facet Bellini, María José
Rodríguez, Gaspar
format Tesis
Tesis de grado
author Rodríguez, Gaspar
author_sort Rodríguez, Gaspar
title Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_short Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_full Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_fullStr Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_full_unstemmed Role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for IGF-I
title_sort role of a-synuclein in proinflammatories processes of neural cells and their regulation by gene therapy for igf-i
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/64897
work_keys_str_mv AT rodriguezgaspar roleofasynucleininproinflammatoriesprocessesofneuralcellsandtheirregulationbygenetherapyforigfi
bdutipo_str Repositorios
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