Bone changes caused by experimental <i>Solanum malacoxylon</i> poisoning in rabbits
The aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant <i>Solanum malacoxylon</i> (syn. <i>S. glaucophyllum</i>) (<i>Sm</i>) during 9 days. The Sm-poisoned rabbits had an increase of bone resorpt...
Guardado en:
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2005
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/35631 http://www.scielo.br/pdf/pvb/v25n1/23871.pdf |
| Aporte de: |
| id |
I19-R120-10915-35631 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Veterinarias bone tissue proteoglycan ruthenium red calcinogenic plant growth plate bone growth rabbit carcinogenicity epiphysis S. Glaucophyllum pathogenesis Solanum malacoxylon trabecular bone Oryctolagus cuniculus |
| spellingShingle |
Ciencias Veterinarias bone tissue proteoglycan ruthenium red calcinogenic plant growth plate bone growth rabbit carcinogenicity epiphysis S. Glaucophyllum pathogenesis Solanum malacoxylon trabecular bone Oryctolagus cuniculus Aguirre, José Ignacio Gomar, María Soledad Igal, Silvio Quiroga, María Alejandra Portiansky, Enrique Leo Gimeno, Eduardo Juan Bone changes caused by experimental <i>Solanum malacoxylon</i> poisoning in rabbits |
| topic_facet |
Ciencias Veterinarias bone tissue proteoglycan ruthenium red calcinogenic plant growth plate bone growth rabbit carcinogenicity epiphysis S. Glaucophyllum pathogenesis Solanum malacoxylon trabecular bone Oryctolagus cuniculus |
| description |
The aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant <i>Solanum malacoxylon</i> (syn. <i>S. glaucophyllum</i>) (<i>Sm</i>) during 9 days. The Sm-poisoned rabbits had an increase of bone resorption in the endosteal surface of the cortical zone and an also in the surface covered by osteoblasts of the primary and secondary spongiosa of the trabecular bone compartment. Moreover, the epiphyseal growth plates in long bones appeared narrower than in the control rabbits, with reduction of the proliferative and hyperthrophic chondrocyte zones. The electron microscopic study revealed a significant decrease of proteoglycans in the hyperthrophic chondrocyte zone evidenced by a significant reduction of rutenium red positive granules in the poisoned rabbit. Altogether, these data suggest that cell differentiation may play a pivotal role in the pathogenesis of <i>Sm</i>-induced bone lesions. |
| format |
Articulo Articulo |
| author |
Aguirre, José Ignacio Gomar, María Soledad Igal, Silvio Quiroga, María Alejandra Portiansky, Enrique Leo Gimeno, Eduardo Juan |
| author_facet |
Aguirre, José Ignacio Gomar, María Soledad Igal, Silvio Quiroga, María Alejandra Portiansky, Enrique Leo Gimeno, Eduardo Juan |
| author_sort |
Aguirre, José Ignacio |
| title |
Bone changes caused by experimental <i>Solanum malacoxylon</i> poisoning in rabbits |
| title_short |
Bone changes caused by experimental <i>Solanum malacoxylon</i> poisoning in rabbits |
| title_full |
Bone changes caused by experimental <i>Solanum malacoxylon</i> poisoning in rabbits |
| title_fullStr |
Bone changes caused by experimental <i>Solanum malacoxylon</i> poisoning in rabbits |
| title_full_unstemmed |
Bone changes caused by experimental <i>Solanum malacoxylon</i> poisoning in rabbits |
| title_sort |
bone changes caused by experimental <i>solanum malacoxylon</i> poisoning in rabbits |
| publishDate |
2005 |
| url |
http://sedici.unlp.edu.ar/handle/10915/35631 http://www.scielo.br/pdf/pvb/v25n1/23871.pdf |
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Repositorios |
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1764820471357898756 |