Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes
The kinetics and mechanism of the thermal decomposition reaction of <i>cis</i>-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in <i>n</i>-hexane and in methanol solutions over the temperatu...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2003
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/35017 http://www.mdpi.com/1420-3049/8/9/655 |
| Aporte de: |
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I19-R120-10915-35017 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Exactas Química alcohol oxidation antimalarial compounds chemical bond fluorophenyl substituted 1,2,4-trioxanes decomposition peroxides high temperature solvent and substituents effects temperature dependence thermal decomposition reactions thermal stimulation thermolysis |
| spellingShingle |
Ciencias Exactas Química alcohol oxidation antimalarial compounds chemical bond fluorophenyl substituted 1,2,4-trioxanes decomposition peroxides high temperature solvent and substituents effects temperature dependence thermal decomposition reactions thermal stimulation thermolysis Cafferata, Lázaro F. R. Rimada, Rubén S. Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| topic_facet |
Ciencias Exactas Química alcohol oxidation antimalarial compounds chemical bond fluorophenyl substituted 1,2,4-trioxanes decomposition peroxides high temperature solvent and substituents effects temperature dependence thermal decomposition reactions thermal stimulation thermolysis |
| description |
The kinetics and mechanism of the thermal decomposition reaction of <i>cis</i>-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in <i>n</i>-hexane and in methanol solutions over the temperature and concentration ranges of 393.2-443.2 K and 2.7-54 × 10<SUP>-5</SUP> M, respectively. The values of the activation parameters for both reactions were compared with the corresponding ones for the thermolysis of <i>cis</i>-6-(4-fluorophenyl-5,6-[2-(4- fluorophenyl)-3-hydroxypropylidene]-3,3-tetramethylene-1,2,4-trioxacyclohexane (II), investigated in the same solvents and temperature range. Substituent and solvent effects on the initial homolytic rupture of the O-O peroxydic bonds of those molecules were evaluated. |
| format |
Articulo Articulo |
| author |
Cafferata, Lázaro F. R. Rimada, Rubén S. |
| author_facet |
Cafferata, Lázaro F. R. Rimada, Rubén S. |
| author_sort |
Cafferata, Lázaro F. R. |
| title |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_short |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_full |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_fullStr |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_full_unstemmed |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_sort |
solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| publishDate |
2003 |
| url |
http://sedici.unlp.edu.ar/handle/10915/35017 http://www.mdpi.com/1420-3049/8/9/655 |
| work_keys_str_mv |
AT cafferatalazarofr solventandsubstituenteffectsonthethermolysisofantimalarialfluorophenylsubstituted124trioxanes AT rimadarubens solventandsubstituenteffectsonthethermolysisofantimalarialfluorophenylsubstituted124trioxanes |
| bdutipo_str |
Repositorios |
| _version_ |
1764820470732947456 |