Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation

Background: Mast cells (MCs) have long been suspected as important players for implantation based on the fact that their degranulation causes the release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in the attachment and posterior invasion of the embry...

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Autores principales: Jensen, Federico, Woudwyk, Mariana Andrea, Teles, Ana, Woidacki, Katja, Taran, Florin, Costa, Serban, Malfertheiner, Sara Fill, Zenclussen, Ana Claudia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Ciencias Veterinarias
Mastocitos
Útero
Hormonas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/29565
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014409
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-29565
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Mastocitos
Útero
Hormonas
spellingShingle Ciencias Veterinarias
Mastocitos
Útero
Hormonas
Jensen, Federico
Woudwyk, Mariana Andrea
Teles, Ana
Woidacki, Katja
Taran, Florin
Costa, Serban
Malfertheiner, Sara Fill
Zenclussen, Ana Claudia
Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation
topic_facet Ciencias Veterinarias
Mastocitos
Útero
Hormonas
description Background: Mast cells (MCs) have long been suspected as important players for implantation based on the fact that their degranulation causes the release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in the attachment and posterior invasion of the embryo into the uterus. Moreover, MC degranulation correlates with angiogenesis during pregnancy. The number of MCs in the uterus has been shown to fluctuate during menstrual cycle in human and estrus cycle in rat and mouse indicating a hormonal influence on their recruitment from the periphery to the uterus. However, the mechanisms behind MC migration to the uterus are still unknown. Methodology/Principal Findings: We first utilized migration assays to show that MCs are able to migrate to the uterus and to the fetal-maternal interface upon up-regulation of the expression of chemokine receptors by hormonal changes. By using a model of ovariectomized animals, we provide clear evidences that also in vivo, estradiol and progesterone attract MC to the uterus and further provoke their maturation and degranulation. Conclusion/Significance: We propose that estradiol and progesterone modulate the migration of MCs from the periphery to the uterus and their degranulation, which may prepare the uterus for implantation.
format Articulo
Articulo
author Jensen, Federico
Woudwyk, Mariana Andrea
Teles, Ana
Woidacki, Katja
Taran, Florin
Costa, Serban
Malfertheiner, Sara Fill
Zenclussen, Ana Claudia
author_facet Jensen, Federico
Woudwyk, Mariana Andrea
Teles, Ana
Woidacki, Katja
Taran, Florin
Costa, Serban
Malfertheiner, Sara Fill
Zenclussen, Ana Claudia
author_sort Jensen, Federico
title Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation
title_short Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation
title_full Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation
title_fullStr Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation
title_full_unstemmed Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation
title_sort estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/29565
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0014409
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