Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)

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The South American species Larrea divaricata Cav. (Zygophyllaceae) has been widely used in folk medicine against infectious diseases. In previous studies, we reported that several extracts obtained from the aerial parts of this species and the nordihydroguaiaretic acid (NDGA), its main lignan, inhib...

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Detalles Bibliográficos
Autores principales:	Konigheim, Brenda S., Aguilar, Juan J., Grasso, Sergio, Contigiani, Marta S., Núñez Montoya, Susana C.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Ácido Nordihidroguaiarético In Vitro Virus Junin Índices HPLC Junin virus Larrea divaricata Nordihydroguaiaretic acid Selectivity index
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/20215 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_3.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-20215
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Ácido Nordihidroguaiarético In Vitro Virus Junin Índices HPLC Junin virus Larrea divaricata Nordihydroguaiaretic acid Selectivity index
spellingShingle	Farmacia Ácido Nordihidroguaiarético In Vitro Virus Junin Índices HPLC Junin virus Larrea divaricata Nordihydroguaiaretic acid Selectivity index Konigheim, Brenda S. Aguilar, Juan J. Grasso, Sergio Contigiani, Marta S. Núñez Montoya, Susana C. Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
topic_facet	Farmacia Ácido Nordihidroguaiarético In Vitro Virus Junin Índices HPLC Junin virus Larrea divaricata Nordihydroguaiaretic acid Selectivity index
description	The South American species Larrea divaricata Cav. (Zygophyllaceae) has been widely used in folk medicine against infectious diseases. In previous studies, we reported that several extracts obtained from the aerial parts of this species and the nordihydroguaiaretic acid (NDGA), its main lignan, inhibited Junin Virus (JUNV) in vitro. In this work, the objective was to assess whether NDGA is truly responsible for the antiviral activity produced by the extracts. Therefore, the presence and amount of NDGA in extracts were determined by HPLC. We established that NDGA in the extracts analyzed is required to inhibit JUNV and observed that some components of the bioactive extracts would increase the antiviral effect of NDGA. On the other hand, we estimated the selectivity index for NDGA against JUNV. Thus, NDGA and extracts containing this lignan exhibited potential therapeutic effects against the etiologic agent of the Argentine Hemorrhagic Fever, an endemo-epidemic illness in this country.
format	Articulo Articulo
author	Konigheim, Brenda S. Aguilar, Juan J. Grasso, Sergio Contigiani, Marta S. Núñez Montoya, Susana C.
author_facet	Konigheim, Brenda S. Aguilar, Juan J. Grasso, Sergio Contigiani, Marta S. Núñez Montoya, Susana C.
author_sort	Konigheim, Brenda S.
title	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_short	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_full	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_fullStr	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_full_unstemmed	Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)
title_sort	incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (zygophyllaceae)
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/20215 http://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_1_3.pdf
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Incidence of the nordihydroguaiaretic acid content on the in vitro antiviral activity of extracts obtained from larrea divaricata cav. (Zygophyllaceae)

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