Solubility of losartan potassium in several mono-solvents at different temperatures

The solubilities of losartan potassium in eight solvents; 1,4-dioxane, acetonitrile, propylene glycol, N-methyl-2-pyrrolidone, 1-butanol, 1-hexanol, 1-heptanol, and 1-octanol, were measured at temperatures ranging from 293.2 to 318.2 K at atmospheric pressure using shake-flask method of Higuchi and...

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Autores principales: Eghrary, Shadi H., Zarghami, Reza, Jouyban, Abolghasem
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Solubilidad
Losartán
Termodinámica
Losartan potassium
Solubility
Thermodynamics
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/20210
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-20210
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Solubilidad
Losartán
Termodinámica
Losartan potassium
Solubility
Thermodynamics
spellingShingle Farmacia
Solubilidad
Losartán
Termodinámica
Losartan potassium
Solubility
Thermodynamics
Eghrary, Shadi H.
Zarghami, Reza
Jouyban, Abolghasem
Solubility of losartan potassium in several mono-solvents at different temperatures
topic_facet Farmacia
Solubilidad
Losartán
Termodinámica
Losartan potassium
Solubility
Thermodynamics
description The solubilities of losartan potassium in eight solvents; 1,4-dioxane, acetonitrile, propylene glycol, N-methyl-2-pyrrolidone, 1-butanol, 1-hexanol, 1-heptanol, and 1-octanol, were measured at temperatures ranging from 293.2 to 318.2 K at atmospheric pressure using shake-flask method of Higuchi and Connors. N-methyl-2-pyrrolidone dissolved the highest amount of losartan potassium and 1,4-dioxane possessed the lowest solubilization power among the investigated solvents. The generated data was used to calculate the thermodynamic parameters of the system using the modified van’t Hoff equation and the Gibbs free energy data was correlated using Abraham solvation parameters.
format Articulo
Comunicacion
author Eghrary, Shadi H.
Zarghami, Reza
Jouyban, Abolghasem
author_facet Eghrary, Shadi H.
Zarghami, Reza
Jouyban, Abolghasem
author_sort Eghrary, Shadi H.
title Solubility of losartan potassium in several mono-solvents at different temperatures
title_short Solubility of losartan potassium in several mono-solvents at different temperatures
title_full Solubility of losartan potassium in several mono-solvents at different temperatures
title_fullStr Solubility of losartan potassium in several mono-solvents at different temperatures
title_full_unstemmed Solubility of losartan potassium in several mono-solvents at different temperatures
title_sort solubility of losartan potassium in several mono-solvents at different temperatures
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/20210
http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_5.pdf
work_keys_str_mv AT eghraryshadih solubilityoflosartanpotassiuminseveralmonosolventsatdifferenttemperatures
AT zarghamireza solubilityoflosartanpotassiuminseveralmonosolventsatdifferenttemperatures
AT jouybanabolghasem solubilityoflosartanpotassiuminseveralmonosolventsatdifferenttemperatures
bdutipo_str Repositorios
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