Use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin

Chitosan microparticles (Cs-MPs) for the dissolution and oral bioavailability improvement of curcumin (Cur) were prepared with sodium tripolyphosphate (TPP) by ionotropic gelation method. Response surface methodology (RSM) based on a three-factor, three-level Box-Behnken Design (BBD), was used to op...

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Detalles Bibliográficos
Autores principales:	Sun, Yingqian, Wan, Shuxin, Zhou, Lijun
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Metodología Curcumina Chitosan microparticles Curcumin Oral bioavailability Response surface methodology Sustained release
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/20190 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_17.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-20190
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Metodología Curcumina Chitosan microparticles Curcumin Oral bioavailability Response surface methodology Sustained release
spellingShingle	Farmacia Metodología Curcumina Chitosan microparticles Curcumin Oral bioavailability Response surface methodology Sustained release Sun, Yingqian Wan, Shuxin Zhou, Lijun Use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin
topic_facet	Farmacia Metodología Curcumina Chitosan microparticles Curcumin Oral bioavailability Response surface methodology Sustained release
description	Chitosan microparticles (Cs-MPs) for the dissolution and oral bioavailability improvement of curcumin (Cur) were prepared with sodium tripolyphosphate (TPP) by ionotropic gelation method. Response surface methodology (RSM) based on a three-factor, three-level Box-Behnken Design (BBD), was used to optimize the preparative conditions of Cs-MPs. The Cs-MPs were characterized for particle size distribution, morphology, X-ray diffractometry, Fourier transform infrared spectroscopy, dissolution profiles, and oral absorption. The optimum conditions were found to be: 1 % of acetic acid concentration, 0.83 of Cs/Cur ratio, 0.15 % of TPP concentration. Loading capacity, encapsulation efficiency and yield of the optimized Cs-MPs were 62.92, 95.41, and 66.20 %, respectively with 83.60 % cumulative release and 18.45 % burst release. Solid-state characterization techniques revealed the decreased crystallinity nature of Cur in Cs-MPs. Cs-MPs provided an improved pharmacokinetic parameter (Cmax = 782.84 ng/mL, tmax = 3.15 h) in rats as compared with pure drug (Cmax = 86.39 ng/mL, tmax = 1.05 h).
format	Articulo Articulo
author	Sun, Yingqian Wan, Shuxin Zhou, Lijun
author_facet	Sun, Yingqian Wan, Shuxin Zhou, Lijun
author_sort	Sun, Yingqian
title	Use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin
title_short	Use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin
title_full	Use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin
title_fullStr	Use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin
title_full_unstemmed	Use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin
title_sort	use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/20190 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_17.pdf
work_keys_str_mv	AT sunyingqian useofresponsesurfacemethodologytooptimizechitosanmicroparticlesforsustainedreleaseofcurcumin AT wanshuxin useofresponsesurfacemethodologytooptimizechitosanmicroparticlesforsustainedreleaseofcurcumin AT zhoulijun useofresponsesurfacemethodologytooptimizechitosanmicroparticlesforsustainedreleaseofcurcumin
bdutipo_str	Repositorios
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Use of response surface methodology to optimize chitosan microparticles for sustained release of curcumin

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