Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats

The plasma pharmacokinetics, tissue distribution, excretion, and metabolism of gambogenic acid (GNA), potential antitumor candidate, were investigated in rats. GNA showed linear pharmacokinetic characteristics in rats within the test dose (1, 2, and 4 mg/kg). The t1/2β was 40.38-41.16 min. GNA showe...

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Detalles Bibliográficos
Autores principales:	Wang, Dianlei, Zhang, Rui, Peng, Daiyin, Chen, Weidong, Zhou, An, Wang, Xiaoshan, Li, Qinglin
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Farmacocinética Distribución Tisular Modalidades de Secreciones y Excreciones Ratas Excretion Gambogenic acid Metabolism Pharmacokinetics Tissue distribution
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/20171 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_3.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-20171
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Farmacocinética Distribución Tisular Modalidades de Secreciones y Excreciones Ratas Excretion Gambogenic acid Metabolism Pharmacokinetics Tissue distribution
spellingShingle	Farmacia Farmacocinética Distribución Tisular Modalidades de Secreciones y Excreciones Ratas Excretion Gambogenic acid Metabolism Pharmacokinetics Tissue distribution Wang, Dianlei Zhang, Rui Peng, Daiyin Chen, Weidong Zhou, An Wang, Xiaoshan Li, Qinglin Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats
topic_facet	Farmacia Farmacocinética Distribución Tisular Modalidades de Secreciones y Excreciones Ratas Excretion Gambogenic acid Metabolism Pharmacokinetics Tissue distribution
description	The plasma pharmacokinetics, tissue distribution, excretion, and metabolism of gambogenic acid (GNA), potential antitumor candidate, were investigated in rats. GNA showed linear pharmacokinetic characteristics in rats within the test dose (1, 2, and 4 mg/kg). The t1/2β was 40.38-41.16 min. GNA showed an extensive distribution into multiple tissues, and the bile excretion is the major pathway of excretion, accounting for 52.12 %. About 40 % of GNA might undergo metabolism in vivo and the main phase I metabolites of GNA may be 10-hydroxygambogenic acid and 9,10-epoxygambogenic acid.
format	Articulo Articulo
author	Wang, Dianlei Zhang, Rui Peng, Daiyin Chen, Weidong Zhou, An Wang, Xiaoshan Li, Qinglin
author_facet	Wang, Dianlei Zhang, Rui Peng, Daiyin Chen, Weidong Zhou, An Wang, Xiaoshan Li, Qinglin
author_sort	Wang, Dianlei
title	Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats
title_short	Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats
title_full	Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats
title_fullStr	Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats
title_full_unstemmed	Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats
title_sort	pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/20171 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_3.pdf
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bdutipo_str	Repositorios
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Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats

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