Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas

Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo...

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Autores principales: Santelices Iglesias, Olga Andrea, Wright, Carolina, Duchene, Adriana Graciela, Risso, Miguel Atilio, Risso, Paula, Zanuzzi, Carolina Natalia, Nishida, Fabián, Lavid, A., Confente, F., Díaz, M., Portiansky, Enrique Leo, Gimeno, Eduardo Juan, Barbeito, Claudio Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Veterinarias
Cat
Cyclo-oxygenase-2
Feline injection site sarcoma
Immunohistochemistry
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/167606
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-167606
record_format dspace
spelling I19-R120-10915-1676062024-06-28T20:10:48Z http://sedici.unlp.edu.ar/handle/10915/167606 Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas Santelices Iglesias, Olga Andrea Wright, Carolina Duchene, Adriana Graciela Risso, Miguel Atilio Risso, Paula Zanuzzi, Carolina Natalia Nishida, Fabián Lavid, A. Confente, F. Díaz, M. Portiansky, Enrique Leo Gimeno, Eduardo Juan Barbeito, Claudio Gustavo 2018 2024-06-28T16:17:53Z en Ciencias Veterinarias Cat Cyclo-oxygenase-2 Feline injection site sarcoma Immunohistochemistry Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)- 2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia. Facultad de Ciencias Veterinarias Articulo Articulo http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) application/pdf 45-51
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Cat
Cyclo-oxygenase-2
Feline injection site sarcoma
Immunohistochemistry
spellingShingle Ciencias Veterinarias
Cat
Cyclo-oxygenase-2
Feline injection site sarcoma
Immunohistochemistry
Santelices Iglesias, Olga Andrea
Wright, Carolina
Duchene, Adriana Graciela
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabián
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
topic_facet Ciencias Veterinarias
Cat
Cyclo-oxygenase-2
Feline injection site sarcoma
Immunohistochemistry
description Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)- 2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.
format Articulo
Articulo
author Santelices Iglesias, Olga Andrea
Wright, Carolina
Duchene, Adriana Graciela
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabián
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author_facet Santelices Iglesias, Olga Andrea
Wright, Carolina
Duchene, Adriana Graciela
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabián
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author_sort Santelices Iglesias, Olga Andrea
title Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_short Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_full Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_fullStr Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_full_unstemmed Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_sort association between degree of anaplasia and degree of inflammation with the expression of cox-2 in feline injection site sarcomas
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/167606
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