Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes

Vismodegib, first approved in 2012 for the treatment of basal cell carcinoma, is an inhibitor of the Hedgehog signaling pathway that becomes active in certain tumors. However, its secondary effects after oral administration and systemic distribution are severe. In this study, we loaded vismodegib in...

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Detalles Bibliográficos
Autores principales: Aguayo Frías, E.T., Maza Vega, Daniela, Calienni, M.N., Melillo, Claudia Marisa, Vazquez, D. S., Alonso, Silvia del Valle, Montanari, Jorge
Formato: Articulo
Lenguaje:Inglés
Publicado: 2023
Materias:
Química
Ethosomes
Liposomes
Drug delivery
Vismodegib
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/160423
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-160423
record_format dspace
spelling I19-R120-10915-1604232023-11-22T20:07:00Z http://sedici.unlp.edu.ar/handle/10915/160423 Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes Aguayo Frías, E.T. Maza Vega, Daniela Calienni, M.N. Melillo, Claudia Marisa Vazquez, D. S. Alonso, Silvia del Valle Montanari, Jorge 2023 2023-11-22T17:46:36Z en Química Ethosomes Liposomes Drug delivery Vismodegib Vismodegib, first approved in 2012 for the treatment of basal cell carcinoma, is an inhibitor of the Hedgehog signaling pathway that becomes active in certain tumors. However, its secondary effects after oral administration and systemic distribution are severe. In this study, we loaded vismodegib into conventional liposomes, which are typically unable to penetrate the stratum corneum barrier effectively after topical application. We studied its skin penetration when coadministered with empty ethosomes, aimed at transiently disrupting the skin impermeability. The drug was successfully recovered from the deeper viable epidermal layers in an in vitro model. The preparation method for the liposomal formulation is reproducible and relatively straightforward to scale up. Furthermore, it involves the use of biocompatible lipids, thus avoiding the utilization of potentially risky compounds. Instituto Multidisciplinario de Biología Celular Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Comisión de Investigaciones Científicas de la provincia de Buenos Aires Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Ethosomes
Liposomes
Drug delivery
Vismodegib
spellingShingle Química
Ethosomes
Liposomes
Drug delivery
Vismodegib
Aguayo Frías, E.T.
Maza Vega, Daniela
Calienni, M.N.
Melillo, Claudia Marisa
Vazquez, D. S.
Alonso, Silvia del Valle
Montanari, Jorge
Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes
topic_facet Química
Ethosomes
Liposomes
Drug delivery
Vismodegib
description Vismodegib, first approved in 2012 for the treatment of basal cell carcinoma, is an inhibitor of the Hedgehog signaling pathway that becomes active in certain tumors. However, its secondary effects after oral administration and systemic distribution are severe. In this study, we loaded vismodegib into conventional liposomes, which are typically unable to penetrate the stratum corneum barrier effectively after topical application. We studied its skin penetration when coadministered with empty ethosomes, aimed at transiently disrupting the skin impermeability. The drug was successfully recovered from the deeper viable epidermal layers in an in vitro model. The preparation method for the liposomal formulation is reproducible and relatively straightforward to scale up. Furthermore, it involves the use of biocompatible lipids, thus avoiding the utilization of potentially risky compounds.
format Articulo
Articulo
author Aguayo Frías, E.T.
Maza Vega, Daniela
Calienni, M.N.
Melillo, Claudia Marisa
Vazquez, D. S.
Alonso, Silvia del Valle
Montanari, Jorge
author_facet Aguayo Frías, E.T.
Maza Vega, Daniela
Calienni, M.N.
Melillo, Claudia Marisa
Vazquez, D. S.
Alonso, Silvia del Valle
Montanari, Jorge
author_sort Aguayo Frías, E.T.
title Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes
title_short Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes
title_full Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes
title_fullStr Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes
title_full_unstemmed Enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes
title_sort enhanced skin delivery of vismodegib-loaded rigid liposomes combined with ethosomes
publishDate 2023
url http://sedici.unlp.edu.ar/handle/10915/160423
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