A mathematical model of receptive field reorganization following stroke

Insufficient blood transport to neurons in the brain due to blocked or ruptured blood vessels (stroke) can lead to damage or death of cells, causing functional impairment. Intact neurons surrounding a stroke-like lesion have been shown to adapt to the damage by expanding their sensory receptive fiel...

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Detalles Bibliográficos
Autores principales:	Einarsdottir, Hildur, Montani, Fernando Fabián, Schultz, Simon R
Formato:	Objeto de conferencia
Lenguaje:	Inglés
Publicado:	2007
Materias:	Física Ingeniería Insufficient blood transport to neurons in the brain Stroke gamma-aminobutyric acid Recovery receptive field plasticity. damaged tissue
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/160201
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-160201
record_format	dspace
spelling	I19-R120-10915-1602012023-11-15T20:06:53Z http://sedici.unlp.edu.ar/handle/10915/160201 A mathematical model of receptive field reorganization following stroke Einarsdottir, Hildur Montani, Fernando Fabián Schultz, Simon R 2007-07 2007 2023-11-15T16:49:52Z en Física Ingeniería Insufficient blood transport to neurons in the brain Stroke gamma-aminobutyric acid Recovery receptive field plasticity. damaged tissue Insufficient blood transport to neurons in the brain due to blocked or ruptured blood vessels (stroke) can lead to damage or death of cells, causing functional impairment. Intact neurons surrounding a stroke-like lesion have been shown to adapt to the damage by expanding their sensory receptive fields in the direction towards the lesion, thereby restoring information processing capacity within the cortex. We developed model of the effect of focal ischaemia on the performance of a neuronal population code, in order to study physiological parameters that could be influenced to enhance recovery from stroke. Our findings show that recovery of the accuracy of the population code is optimal by a specific amount of receptive field plasticity. This plasticity may be influenced by changing the level of gamma-aminobutyric acid (GABA-ergic) inhibition in the areas surrounding the damaged tissue. Facultad de Ciencias Exactas Objeto de conferencia Objeto de conferencia http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Física Ingeniería Insufficient blood transport to neurons in the brain Stroke gamma-aminobutyric acid Recovery receptive field plasticity. damaged tissue
spellingShingle	Física Ingeniería Insufficient blood transport to neurons in the brain Stroke gamma-aminobutyric acid Recovery receptive field plasticity. damaged tissue Einarsdottir, Hildur Montani, Fernando Fabián Schultz, Simon R A mathematical model of receptive field reorganization following stroke
topic_facet	Física Ingeniería Insufficient blood transport to neurons in the brain Stroke gamma-aminobutyric acid Recovery receptive field plasticity. damaged tissue
description	Insufficient blood transport to neurons in the brain due to blocked or ruptured blood vessels (stroke) can lead to damage or death of cells, causing functional impairment. Intact neurons surrounding a stroke-like lesion have been shown to adapt to the damage by expanding their sensory receptive fields in the direction towards the lesion, thereby restoring information processing capacity within the cortex. We developed model of the effect of focal ischaemia on the performance of a neuronal population code, in order to study physiological parameters that could be influenced to enhance recovery from stroke. Our findings show that recovery of the accuracy of the population code is optimal by a specific amount of receptive field plasticity. This plasticity may be influenced by changing the level of gamma-aminobutyric acid (GABA-ergic) inhibition in the areas surrounding the damaged tissue.
format	Objeto de conferencia Objeto de conferencia
author	Einarsdottir, Hildur Montani, Fernando Fabián Schultz, Simon R
author_facet	Einarsdottir, Hildur Montani, Fernando Fabián Schultz, Simon R
author_sort	Einarsdottir, Hildur
title	A mathematical model of receptive field reorganization following stroke
title_short	A mathematical model of receptive field reorganization following stroke
title_full	A mathematical model of receptive field reorganization following stroke
title_fullStr	A mathematical model of receptive field reorganization following stroke
title_full_unstemmed	A mathematical model of receptive field reorganization following stroke
title_sort	mathematical model of receptive field reorganization following stroke
publishDate	2007
url	http://sedici.unlp.edu.ar/handle/10915/160201
work_keys_str_mv	AT einarsdottirhildur amathematicalmodelofreceptivefieldreorganizationfollowingstroke AT montanifernandofabian amathematicalmodelofreceptivefieldreorganizationfollowingstroke AT schultzsimonr amathematicalmodelofreceptivefieldreorganizationfollowingstroke AT einarsdottirhildur mathematicalmodelofreceptivefieldreorganizationfollowingstroke AT montanifernandofabian mathematicalmodelofreceptivefieldreorganizationfollowingstroke AT schultzsimonr mathematicalmodelofreceptivefieldreorganizationfollowingstroke
_version_	1807221849433571328

A mathematical model of receptive field reorganization following stroke

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