The entomopathogenic fungus Beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis

Entomopathogenic fungi are extensively used for the control of insect pests worldwide. Among them, Beauveria bassiana (Ascomycota: Hypocreales) produce a plethora of toxic secondary metabolites that either facilitate fungal invasion or act as immunosuppressive compounds. These toxins have different...

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Autor principal: Pedrini, Nicolás
Formato: Articulo
Lenguaje:Inglés
Publicado: 2022
Materias:
Biología
entomopathogenic fungi
virulence
nonribosomal peptides (NRPS)
polyketides (PKS)
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/156300
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-156300
record_format dspace
spelling I19-R120-10915-1563002023-08-14T20:09:00Z http://sedici.unlp.edu.ar/handle/10915/156300 The entomopathogenic fungus Beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis Pedrini, Nicolás 2022 2023-08-14T17:56:10Z en Biología entomopathogenic fungi virulence nonribosomal peptides (NRPS) polyketides (PKS) Entomopathogenic fungi are extensively used for the control of insect pests worldwide. Among them, Beauveria bassiana (Ascomycota: Hypocreales) produce a plethora of toxic secondary metabolites that either facilitate fungal invasion or act as immunosuppressive compounds. These toxins have different chemical natures, such as nonribosomal peptides and polyketides. Even though their precise role is poorly understood, they are usually linked to virulence. These fungal secondary metabolites are produced by the expression of gene clusters encoding the various proteins needed for their biosynthesis. Each cluster includes synthetases for nonribosomal peptides (NRPS), polyketides (PKS), or hybrid NRPS–PKS genes. The aim of this review is to summarize the information available from transcriptomics and quantitative PCR studies related to the expression of B. bassiana NRPS and PKS genes inside different insects as the infection progresses; as for the host immune response, to help understand the mechanisms that these toxins trigger as virulence factors, antimicrobials, or immunosuppressives within the context of a fungus–insect interaction. Instituto de Investigaciones Bioquímicas de La Plata Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
entomopathogenic fungi
virulence
nonribosomal peptides (NRPS)
polyketides (PKS)
spellingShingle Biología
entomopathogenic fungi
virulence
nonribosomal peptides (NRPS)
polyketides (PKS)
Pedrini, Nicolás
The entomopathogenic fungus Beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis
topic_facet Biología
entomopathogenic fungi
virulence
nonribosomal peptides (NRPS)
polyketides (PKS)
description Entomopathogenic fungi are extensively used for the control of insect pests worldwide. Among them, Beauveria bassiana (Ascomycota: Hypocreales) produce a plethora of toxic secondary metabolites that either facilitate fungal invasion or act as immunosuppressive compounds. These toxins have different chemical natures, such as nonribosomal peptides and polyketides. Even though their precise role is poorly understood, they are usually linked to virulence. These fungal secondary metabolites are produced by the expression of gene clusters encoding the various proteins needed for their biosynthesis. Each cluster includes synthetases for nonribosomal peptides (NRPS), polyketides (PKS), or hybrid NRPS–PKS genes. The aim of this review is to summarize the information available from transcriptomics and quantitative PCR studies related to the expression of B. bassiana NRPS and PKS genes inside different insects as the infection progresses; as for the host immune response, to help understand the mechanisms that these toxins trigger as virulence factors, antimicrobials, or immunosuppressives within the context of a fungus–insect interaction.
format Articulo
Articulo
author Pedrini, Nicolás
author_facet Pedrini, Nicolás
author_sort Pedrini, Nicolás
title The entomopathogenic fungus Beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis
title_short The entomopathogenic fungus Beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis
title_full The entomopathogenic fungus Beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis
title_fullStr The entomopathogenic fungus Beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis
title_full_unstemmed The entomopathogenic fungus Beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis
title_sort entomopathogenic fungus beauveria bassiana shows its toxic side within insects: expression of genes encoding secondary metabolites during pathogenesis
publishDate 2022
url http://sedici.unlp.edu.ar/handle/10915/156300
work_keys_str_mv AT pedrininicolas theentomopathogenicfungusbeauveriabassianashowsitstoxicsidewithininsectsexpressionofgenesencodingsecondarymetabolitesduringpathogenesis
AT pedrininicolas entomopathogenicfungusbeauveriabassianashowsitstoxicsidewithininsectsexpressionofgenesencodingsecondarymetabolitesduringpathogenesis
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