Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity

After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and vaccination schedules has become the subject of continuous interest. As a re...

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Autores principales:	Szwejser-Zawislak, Ewa, Wilk, Mieszko M., Piszczek, Piotr, Krawczyk, Justyna, Wilczyńska, Daria, Hozbor, Daniela Flavia
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2023
Materias:	Ciencias Exactas Biología pertussis Bordetella pertussis acellular pertussis vaccine whole cell pertussis vaccine DTaP Tdap DTwP
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/153908
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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record_format	dspace
spelling	I19-R120-10915-1539082023-06-06T04:06:45Z http://sedici.unlp.edu.ar/handle/10915/153908 issn:2076-393X Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity Szwejser-Zawislak, Ewa Wilk, Mieszko M. Piszczek, Piotr Krawczyk, Justyna Wilczyńska, Daria Hozbor, Daniela Flavia 2023-01 2023-06-05T14:22:34Z en Ciencias Exactas Biología pertussis Bordetella pertussis acellular pertussis vaccine whole cell pertussis vaccine DTaP Tdap DTwP After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and vaccination schedules has become the subject of continuous interest. As a result, we are witnessing a considerable heterogeneity in pertussis vaccination policies, which remains beyond universal consensus. Many pertussis-related deaths still occur in low- and middle-income countries; however, these deaths are attributable to gaps in vaccination coverage and limited access to healthcare in these countries, rather than to the poor efficacy of the first generation of pertussis vaccine consisting in inactivated and detoxified whole cell pathogen (wP). In many, particularly high-income countries, a switch was made in the 1990s to the use of acellular pertussis (aP) vaccine, to reduce the rate of post-vaccination adverse events and thereby achieve a higher percentage of children vaccinated. However the epidemiological data collected over the past few decades, even in those high-income countries, show an increase in pertussis prevalence and morbidity rates, triggering a wide-ranging debate on the causes of pertussis resurgence and the effectiveness of current pertussis prevention strategies, as well as on the efficacy of available pertussis vaccines and immunization schedules. The current article presents a systematic review of scientific reports on the evaluation of the use of whole-cell and acellular pertussis vaccines, in the context of long-term immunity and vaccines efficacy. Instituto de Biotecnología y Biología Molecular Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Biología pertussis Bordetella pertussis acellular pertussis vaccine whole cell pertussis vaccine DTaP Tdap DTwP
spellingShingle	Ciencias Exactas Biología pertussis Bordetella pertussis acellular pertussis vaccine whole cell pertussis vaccine DTaP Tdap DTwP Szwejser-Zawislak, Ewa Wilk, Mieszko M. Piszczek, Piotr Krawczyk, Justyna Wilczyńska, Daria Hozbor, Daniela Flavia Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity
topic_facet	Ciencias Exactas Biología pertussis Bordetella pertussis acellular pertussis vaccine whole cell pertussis vaccine DTaP Tdap DTwP
description	After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and vaccination schedules has become the subject of continuous interest. As a result, we are witnessing a considerable heterogeneity in pertussis vaccination policies, which remains beyond universal consensus. Many pertussis-related deaths still occur in low- and middle-income countries; however, these deaths are attributable to gaps in vaccination coverage and limited access to healthcare in these countries, rather than to the poor efficacy of the first generation of pertussis vaccine consisting in inactivated and detoxified whole cell pathogen (wP). In many, particularly high-income countries, a switch was made in the 1990s to the use of acellular pertussis (aP) vaccine, to reduce the rate of post-vaccination adverse events and thereby achieve a higher percentage of children vaccinated. However the epidemiological data collected over the past few decades, even in those high-income countries, show an increase in pertussis prevalence and morbidity rates, triggering a wide-ranging debate on the causes of pertussis resurgence and the effectiveness of current pertussis prevention strategies, as well as on the efficacy of available pertussis vaccines and immunization schedules. The current article presents a systematic review of scientific reports on the evaluation of the use of whole-cell and acellular pertussis vaccines, in the context of long-term immunity and vaccines efficacy.
format	Articulo Articulo
author	Szwejser-Zawislak, Ewa Wilk, Mieszko M. Piszczek, Piotr Krawczyk, Justyna Wilczyńska, Daria Hozbor, Daniela Flavia
author_facet	Szwejser-Zawislak, Ewa Wilk, Mieszko M. Piszczek, Piotr Krawczyk, Justyna Wilczyńska, Daria Hozbor, Daniela Flavia
author_sort	Szwejser-Zawislak, Ewa
title	Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity
title_short	Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity
title_full	Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity
title_fullStr	Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity
title_full_unstemmed	Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity
title_sort	evaluation of whole-cell and acellular pertussis vaccines in the context of long-term herd immunity
publishDate	2023
url	http://sedici.unlp.edu.ar/handle/10915/153908
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Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity

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