Tissue Depletion Profile of Ivermectin in Rabbits

Avermectins are largely used in different animal species. Ivermectin, the most popular avermectin, is used against a wide spectrum of endo and ectoparasites. Some mange mites are particularly sensitive to ivermectin. Notoedres cati var. cuniculi, the agent of rabbit mange, is particularly sensitive...

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Autores principales: Marchetti, María Laura, Buldain, Daniel Cornelio, Buchamer, Andrea Verónica, Zeinsteger, Pedro Adolfo, Mestorino, Olga Nora
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Veterinarias
Ivermectin
Tissues
Residues
Withdrawal Time
Rabbit
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/153598
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-153598
record_format dspace
spelling I19-R120-10915-1535982023-05-29T20:09:20Z http://sedici.unlp.edu.ar/handle/10915/153598 issn:2306-7381 Tissue Depletion Profile of Ivermectin in Rabbits Marchetti, María Laura Buldain, Daniel Cornelio Buchamer, Andrea Verónica Zeinsteger, Pedro Adolfo Mestorino, Olga Nora 2020-07-11 2023-05-29T18:36:46Z en Ciencias Veterinarias Ivermectin Tissues Residues Withdrawal Time Rabbit Avermectins are largely used in different animal species. Ivermectin, the most popular avermectin, is used against a wide spectrum of endo and ectoparasites. Some mange mites are particularly sensitive to ivermectin. Notoedres cati var. cuniculi, the agent of rabbit mange, is particularly sensitive to ivermectin. Pharmacokinetic and residual studies of ivermectin in rabbits, however, are scarce. The objective of the present paper was to study the tissue residue profile of ivermectin (IVM) after subcutaneous (s.c.) administration of a 1% w/w solution. Sixteen young healthy male rabbits received 200 μg/kg of a 1% w/w ivermectin formulation subcutaneously. Groups of four treated animals were sacrificed at 10, 20, 30 and 40 days after injection. Samples of liver, fat, kidney and muscle tissue were obtained. IVM concentrations were determined by liquid chromatography with fluorescence detection after automatic solid phase extraction with SPE C18 cartridges. Ivermectin was detected after subcutaneous administration until 40 days. Muscle samples showed the lowest IVM concentrations throughout the study. The highest IVM concentrations at all sampling times were measured in liver and fat tissues. Nevertheless, IVM concentrations in all the tissues analyzed were below the accepted maximum residue limits recommended by the European Union at 20 days posttreatment. Facultad de Ciencias Veterinarias Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 62-71
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Ivermectin
Tissues
Residues
Withdrawal Time
Rabbit
spellingShingle Ciencias Veterinarias
Ivermectin
Tissues
Residues
Withdrawal Time
Rabbit
Marchetti, María Laura
Buldain, Daniel Cornelio
Buchamer, Andrea Verónica
Zeinsteger, Pedro Adolfo
Mestorino, Olga Nora
Tissue Depletion Profile of Ivermectin in Rabbits
topic_facet Ciencias Veterinarias
Ivermectin
Tissues
Residues
Withdrawal Time
Rabbit
description Avermectins are largely used in different animal species. Ivermectin, the most popular avermectin, is used against a wide spectrum of endo and ectoparasites. Some mange mites are particularly sensitive to ivermectin. Notoedres cati var. cuniculi, the agent of rabbit mange, is particularly sensitive to ivermectin. Pharmacokinetic and residual studies of ivermectin in rabbits, however, are scarce. The objective of the present paper was to study the tissue residue profile of ivermectin (IVM) after subcutaneous (s.c.) administration of a 1% w/w solution. Sixteen young healthy male rabbits received 200 μg/kg of a 1% w/w ivermectin formulation subcutaneously. Groups of four treated animals were sacrificed at 10, 20, 30 and 40 days after injection. Samples of liver, fat, kidney and muscle tissue were obtained. IVM concentrations were determined by liquid chromatography with fluorescence detection after automatic solid phase extraction with SPE C18 cartridges. Ivermectin was detected after subcutaneous administration until 40 days. Muscle samples showed the lowest IVM concentrations throughout the study. The highest IVM concentrations at all sampling times were measured in liver and fat tissues. Nevertheless, IVM concentrations in all the tissues analyzed were below the accepted maximum residue limits recommended by the European Union at 20 days posttreatment.
format Articulo
Articulo
author Marchetti, María Laura
Buldain, Daniel Cornelio
Buchamer, Andrea Verónica
Zeinsteger, Pedro Adolfo
Mestorino, Olga Nora
author_facet Marchetti, María Laura
Buldain, Daniel Cornelio
Buchamer, Andrea Verónica
Zeinsteger, Pedro Adolfo
Mestorino, Olga Nora
author_sort Marchetti, María Laura
title Tissue Depletion Profile of Ivermectin in Rabbits
title_short Tissue Depletion Profile of Ivermectin in Rabbits
title_full Tissue Depletion Profile of Ivermectin in Rabbits
title_fullStr Tissue Depletion Profile of Ivermectin in Rabbits
title_full_unstemmed Tissue Depletion Profile of Ivermectin in Rabbits
title_sort tissue depletion profile of ivermectin in rabbits
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/153598
work_keys_str_mv AT marchettimarialaura tissuedepletionprofileofivermectininrabbits
AT buldaindanielcornelio tissuedepletionprofileofivermectininrabbits
AT buchamerandreaveronica tissuedepletionprofileofivermectininrabbits
AT zeinstegerpedroadolfo tissuedepletionprofileofivermectininrabbits
AT mestorinoolganora tissuedepletionprofileofivermectininrabbits
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