Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin

The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C. In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added into the cryogel (PVA–P). A film contai...

Descripción completa

Detalles Bibliográficos
Autores principales: Martínez, Yanina, Piñuel, Lucrecia, Castro, Guillermo Raúl, Breccia, Javier D.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Bioquímica
Transcutaneous delivery
Enrofloxacin
PVA
Pectin
Films
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/153289
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-153289
record_format dspace
spelling I19-R120-10915-1532892023-05-20T04:06:03Z http://sedici.unlp.edu.ar/handle/10915/153289 issn:1559-0291 issn:0273-2289 Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin Martínez, Yanina Piñuel, Lucrecia Castro, Guillermo Raúl Breccia, Javier D. 2012 2023-05-19T16:12:23Z en Bioquímica Transcutaneous delivery Enrofloxacin PVA Pectin Films The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C. In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added into the cryogel (PVA–P). A film containing 1.0% (w/v) HM pectin and 5.0 μg/ml enrofloxacin released only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showed that most of the interactions between PVA–P matrix and enrofloxacin were due to polar groups (carboxylate and amine), a two-layer film system was designed to modulate the releasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to 41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacin was found dependent on NaCl concentration in the upper gel layer. The two-layer cryogel system showed attractive features for transcutaneous antibiotic delivery. Centro de Investigación y Desarrollo en Fermentaciones Industriales Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 1421-1429
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Transcutaneous delivery
Enrofloxacin
PVA
Pectin
Films
spellingShingle Bioquímica
Transcutaneous delivery
Enrofloxacin
PVA
Pectin
Films
Martínez, Yanina
Piñuel, Lucrecia
Castro, Guillermo Raúl
Breccia, Javier D.
Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
topic_facet Bioquímica
Transcutaneous delivery
Enrofloxacin
PVA
Pectin
Films
description The release of enrofloxacin entrapped in polyvinyl alcohol (PVA) cryogel at pH 5.5 showed a first-order kinetic, releasing 69.7% of the antibiotic after 4.5 h at 37 °C. In order to slow down the fluoroquinolone release rate, high-methoxylated pectin was added into the cryogel (PVA–P). A film containing 1.0% (w/v) HM pectin and 5.0 μg/ml enrofloxacin released only 3.7% of the antibiotic after 4.5 h. Since the FTIR spectrum showed that most of the interactions between PVA–P matrix and enrofloxacin were due to polar groups (carboxylate and amine), a two-layer film system was designed to modulate the releasing rate of the drug. The top film equilibrated with 0.75 or 1.5 M NaCl release up to 41.9% and 89.0% of the enrofloxacin in 4 h, respectively. The release rate of enrofloxacin was found dependent on NaCl concentration in the upper gel layer. The two-layer cryogel system showed attractive features for transcutaneous antibiotic delivery.
format Articulo
Articulo
author Martínez, Yanina
Piñuel, Lucrecia
Castro, Guillermo Raúl
Breccia, Javier D.
author_facet Martínez, Yanina
Piñuel, Lucrecia
Castro, Guillermo Raúl
Breccia, Javier D.
author_sort Martínez, Yanina
title Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_short Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_full Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_fullStr Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_full_unstemmed Polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
title_sort polyvinyl alcohol–pectin cryogel films for controlled release of enrofloxacin
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/153289
work_keys_str_mv AT martinezyanina polyvinylalcoholpectincryogelfilmsforcontrolledreleaseofenrofloxacin
AT pinuellucrecia polyvinylalcoholpectincryogelfilmsforcontrolledreleaseofenrofloxacin
AT castroguillermoraul polyvinylalcoholpectincryogelfilmsforcontrolledreleaseofenrofloxacin
AT brecciajavierd polyvinylalcoholpectincryogelfilmsforcontrolledreleaseofenrofloxacin
_version_ 1766999717368037376

Ejemplares similares