Cereal Proteins: Immunostimulatory and Toxic Peptides

Storage proteins from wheat kernels are the base of a wide variety of homemade and industrial food products. Nonetheless, for a group of individuals (celiac disease (CD) patients), these proteins are toxic. Gliadins and glutenins from wheat, as well as their counterparts in barley and rye, also cal...

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Autores principales: Chirdo, Fernando Gabriel, Arranz, Eduardo, Fernández Bañares, Fernando, Rosell, Cristina M., Amado, Luis Rodrigo, Peña, Salvador
Formato: Libro Capitulo de libro
Lenguaje:Inglés
Publicado: OmniaScience 2015
Materias:
Biología
Gliadins
glutenins
prolamins
toxic proteins
gluten analysis
immune response
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/152536
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-152536
record_format dspace
spelling I19-R120-10915-1525362023-05-06T04:06:07Z http://sedici.unlp.edu.ar/handle/10915/152536 isbn:978-84-943418-2-3 Cereal Proteins: Immunostimulatory and Toxic Peptides Chirdo, Fernando Gabriel Arranz, Eduardo 2015 2023-05-05T17:41:44Z Arranz, Eduardo Fernández Bañares, Fernando Rosell, Cristina M. Amado, Luis Rodrigo Peña, Salvador OmniaScience en Biología Gliadins glutenins prolamins toxic proteins gluten analysis immune response Storage proteins from wheat kernels are the base of a wide variety of homemade and industrial food products. Nonetheless, for a group of individuals (celiac disease (CD) patients), these proteins are toxic. Gliadins and glutenins from wheat, as well as their counterparts in barley and rye, also called prolamins, are evolutionary related, and present a high degree of homology. Polyclonal and monoclonal antibodies raised against prolamins have been a very useful tool to characterise structural and conformational features of prolamins, and particularly, for gluten analysis based on immunochemical techniques. Complete adherence to a gluten-free diet is required to recover the normal histology of the small intestine in CD patients. To this end, the use of certified gluten-free products is mandatory. Aqueous solvents such as 60-70% ethanol, have been used for extraction of prolamins from flours and food. This method is not selective and, therefore, results in complex mixtures of proteins which together with their low solubility in aqueous solutions, high degree of homology, and consequently crossreactivity, produce some drawbacks in gluten analysis by immunoassays. Prolamins drive an exacerbated immune response in intestinal mucosa of CD patients. T lymphocytes are a central piece in CD pathogenesis. However, new insights in the knowledge of innate immunity point out to some gliadin peptides which can also produce structural changes in the intestine as well as inflammatory reactions. Instituto de Estudios Inmunológicos y Fisiopatológicos Libro Capitulo de libro http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 141-162
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Gliadins
glutenins
prolamins
toxic proteins
gluten analysis
immune response
spellingShingle Biología
Gliadins
glutenins
prolamins
toxic proteins
gluten analysis
immune response
Chirdo, Fernando Gabriel
Arranz, Eduardo
Arranz, Eduardo
Fernández Bañares, Fernando
Rosell, Cristina M.
Amado, Luis Rodrigo
Peña, Salvador
Cereal Proteins: Immunostimulatory and Toxic Peptides
topic_facet Biología
Gliadins
glutenins
prolamins
toxic proteins
gluten analysis
immune response
description Storage proteins from wheat kernels are the base of a wide variety of homemade and industrial food products. Nonetheless, for a group of individuals (celiac disease (CD) patients), these proteins are toxic. Gliadins and glutenins from wheat, as well as their counterparts in barley and rye, also called prolamins, are evolutionary related, and present a high degree of homology. Polyclonal and monoclonal antibodies raised against prolamins have been a very useful tool to characterise structural and conformational features of prolamins, and particularly, for gluten analysis based on immunochemical techniques. Complete adherence to a gluten-free diet is required to recover the normal histology of the small intestine in CD patients. To this end, the use of certified gluten-free products is mandatory. Aqueous solvents such as 60-70% ethanol, have been used for extraction of prolamins from flours and food. This method is not selective and, therefore, results in complex mixtures of proteins which together with their low solubility in aqueous solutions, high degree of homology, and consequently crossreactivity, produce some drawbacks in gluten analysis by immunoassays. Prolamins drive an exacerbated immune response in intestinal mucosa of CD patients. T lymphocytes are a central piece in CD pathogenesis. However, new insights in the knowledge of innate immunity point out to some gliadin peptides which can also produce structural changes in the intestine as well as inflammatory reactions.
format Libro
Capitulo de libro
author Chirdo, Fernando Gabriel
Arranz, Eduardo
Arranz, Eduardo
Fernández Bañares, Fernando
Rosell, Cristina M.
Amado, Luis Rodrigo
Peña, Salvador
author_facet Chirdo, Fernando Gabriel
Arranz, Eduardo
Arranz, Eduardo
Fernández Bañares, Fernando
Rosell, Cristina M.
Amado, Luis Rodrigo
Peña, Salvador
author_sort Chirdo, Fernando Gabriel
title Cereal Proteins: Immunostimulatory and Toxic Peptides
title_short Cereal Proteins: Immunostimulatory and Toxic Peptides
title_full Cereal Proteins: Immunostimulatory and Toxic Peptides
title_fullStr Cereal Proteins: Immunostimulatory and Toxic Peptides
title_full_unstemmed Cereal Proteins: Immunostimulatory and Toxic Peptides
title_sort cereal proteins: immunostimulatory and toxic peptides
publisher OmniaScience
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/152536
work_keys_str_mv AT chirdofernandogabriel cerealproteinsimmunostimulatoryandtoxicpeptides
AT arranzeduardo cerealproteinsimmunostimulatoryandtoxicpeptides
AT arranzeduardo cerealproteinsimmunostimulatoryandtoxicpeptides
AT fernandezbanaresfernando cerealproteinsimmunostimulatoryandtoxicpeptides
AT rosellcristinam cerealproteinsimmunostimulatoryandtoxicpeptides
AT amadoluisrodrigo cerealproteinsimmunostimulatoryandtoxicpeptides
AT penasalvador cerealproteinsimmunostimulatoryandtoxicpeptides
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