Implication of Oxidative Stress, Aging, and Inflammatory Processes in Neurodegenerative Diseases: Growth Factors as Therapeutic Approach

Oxidative stress (OS) is defined as the imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system. Living organisms produce ROS from molecular oxygen as a consequence of normal cellular metabolism. In order to prevent damage, cells have an antioxidant defen...

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Autores principales: Herrera, Macarena Lorena, Falomir Lockhart, Eugenia, Dolcetti, Franco Juan Cruz, Arnal, Nathalie, Bellini, María José, Hereñú, Claudia Beatriz, Gargiulo, Pascual Ángel, Mesones Arroyo, Humberto Luis
Formato: Libro Capitulo de libro
Lenguaje:Inglés
Publicado: Springer 2019
Materias:
Ciencias Médicas
Neurodegeneración
Estrés oxidativo
Especies reactivas del oxígeno
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/152419
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SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-152419
record_format dspace
spelling I19-R120-10915-1524192023-05-03T20:09:08Z http://sedici.unlp.edu.ar/handle/10915/152419 isbn:978-3-319-95360-1 Implication of Oxidative Stress, Aging, and Inflammatory Processes in Neurodegenerative Diseases: Growth Factors as Therapeutic Approach Herrera, Macarena Lorena Falomir Lockhart, Eugenia Dolcetti, Franco Juan Cruz Arnal, Nathalie Bellini, María José Hereñú, Claudia Beatriz 2019 2023-05-03T18:30:42Z Gargiulo, Pascual Ángel Mesones Arroyo, Humberto Luis Springer en Ciencias Médicas Neurodegeneración Estrés oxidativo Especies reactivas del oxígeno Oxidative stress (OS) is defined as the imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system. Living organisms produce ROS from molecular oxygen as a consequence of normal cellular metabolism. In order to prevent damage, cells have an antioxidant defense system constituted by an enzymatic component (including catalases, superoxide dismutases, etc.) and nonenzymatic antioxidants component (glutathione, α-tocopherol, ascorbic acid, etc.). When the levels of ROS exceed cell capacity, it can cause damage in cellular components such as carbohydrates, nucleic acids, lipids, and proteins, thus altering their function. Whenever this imbalance occurs within the central nervous system, it can lead to the development of the neurodegenerative disorders. Neurodegenerative diseases are characterized by the loss of neuronal cells and, in most cases, by the aggregates of proteins that form intracytoplasmic and intranuclear inclusions in neurons and glial cells. Data on the literature show that there are two possible mechanisms involved in most of neurodegenerative diseases: (1) mutations and/or aggregation of characteristic proteins of each disease such as α-synuclein in Parkinson’s disease (PD) or beta-amyloid peptide in Alzheimer’s disease (AD) and (2) dysfunction of mitochondrial energy metabolism in neurons. In this section, we will focus on this last one. Instituto de Investigaciones Bioquímicas de La Plata Libro Capitulo de libro http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 165-176
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Neurodegeneración
Estrés oxidativo
Especies reactivas del oxígeno
spellingShingle Ciencias Médicas
Neurodegeneración
Estrés oxidativo
Especies reactivas del oxígeno
Herrera, Macarena Lorena
Falomir Lockhart, Eugenia
Dolcetti, Franco Juan Cruz
Arnal, Nathalie
Bellini, María José
Hereñú, Claudia Beatriz
Gargiulo, Pascual Ángel
Mesones Arroyo, Humberto Luis
Implication of Oxidative Stress, Aging, and Inflammatory Processes in Neurodegenerative Diseases: Growth Factors as Therapeutic Approach
topic_facet Ciencias Médicas
Neurodegeneración
Estrés oxidativo
Especies reactivas del oxígeno
description Oxidative stress (OS) is defined as the imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system. Living organisms produce ROS from molecular oxygen as a consequence of normal cellular metabolism. In order to prevent damage, cells have an antioxidant defense system constituted by an enzymatic component (including catalases, superoxide dismutases, etc.) and nonenzymatic antioxidants component (glutathione, α-tocopherol, ascorbic acid, etc.). When the levels of ROS exceed cell capacity, it can cause damage in cellular components such as carbohydrates, nucleic acids, lipids, and proteins, thus altering their function. Whenever this imbalance occurs within the central nervous system, it can lead to the development of the neurodegenerative disorders. Neurodegenerative diseases are characterized by the loss of neuronal cells and, in most cases, by the aggregates of proteins that form intracytoplasmic and intranuclear inclusions in neurons and glial cells. Data on the literature show that there are two possible mechanisms involved in most of neurodegenerative diseases: (1) mutations and/or aggregation of characteristic proteins of each disease such as α-synuclein in Parkinson’s disease (PD) or beta-amyloid peptide in Alzheimer’s disease (AD) and (2) dysfunction of mitochondrial energy metabolism in neurons. In this section, we will focus on this last one.
format Libro
Capitulo de libro
author Herrera, Macarena Lorena
Falomir Lockhart, Eugenia
Dolcetti, Franco Juan Cruz
Arnal, Nathalie
Bellini, María José
Hereñú, Claudia Beatriz
Gargiulo, Pascual Ángel
Mesones Arroyo, Humberto Luis
author_facet Herrera, Macarena Lorena
Falomir Lockhart, Eugenia
Dolcetti, Franco Juan Cruz
Arnal, Nathalie
Bellini, María José
Hereñú, Claudia Beatriz
Gargiulo, Pascual Ángel
Mesones Arroyo, Humberto Luis
author_sort Herrera, Macarena Lorena
title Implication of Oxidative Stress, Aging, and Inflammatory Processes in Neurodegenerative Diseases: Growth Factors as Therapeutic Approach
title_short Implication of Oxidative Stress, Aging, and Inflammatory Processes in Neurodegenerative Diseases: Growth Factors as Therapeutic Approach
title_full Implication of Oxidative Stress, Aging, and Inflammatory Processes in Neurodegenerative Diseases: Growth Factors as Therapeutic Approach
title_fullStr Implication of Oxidative Stress, Aging, and Inflammatory Processes in Neurodegenerative Diseases: Growth Factors as Therapeutic Approach
title_full_unstemmed Implication of Oxidative Stress, Aging, and Inflammatory Processes in Neurodegenerative Diseases: Growth Factors as Therapeutic Approach
title_sort implication of oxidative stress, aging, and inflammatory processes in neurodegenerative diseases: growth factors as therapeutic approach
publisher Springer
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/152419
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