Statin Related Myopathy and Vitamin D

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Statins are usually safe and well tolerated drugs, very effective for cardiovascular prevention. The presence of myopathy, rare, but with different incidence in different reports, is one of the causes of abandonment of its use. It has begun to report association between decreased vitamin D levels an...

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Autor principal: Mansur, José Luis
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Medicina
Vitamin D
statins
Statin-Related Myopathy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/151970
https://gratisoa.org/journals/index.php/ACEM/article/view/1382
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-151970
record_format dspace
spelling I19-R120-10915-1519702023-04-21T20:38:49Z http://sedici.unlp.edu.ar/handle/10915/151970 https://gratisoa.org/journals/index.php/ACEM/article/view/1382 issn:2641-6425 Statin Related Myopathy and Vitamin D Mansur, José Luis 2018 2023-04-21T16:48:21Z en Medicina Vitamin D statins Statin-Related Myopathy Statins are usually safe and well tolerated drugs, very effective for cardiovascular prevention. The presence of myopathy, rare, but with different incidence in different reports, is one of the causes of abandonment of its use. It has begun to report association between decreased vitamin D levels and increased risk of myopathy, on the one hand, and reports where patients who stop statins consumption due to myalgia, with vitamin D deficiency, can tolerate these drugs once the vitamin is supplemented to values desirable Another factor clearly related to myopathy is the presence of polymorphisms in enzyme genes that metabolize or transport statins. As many patients with vitamin D deficiency do not have pain or are completely asymptomatic (with or without statins), we may consider it as a risk factor for developing myopathy due to statins (such as the simultaneous administration of drugs that are metabolized by the same cytochrome P450 pathway, or the presence of mentioned polymorphisms). In conclusion, the finding that having Vitamin D deficiency is associated with statin myopathy, or is a risk factor to develop it, opens new perspectives for a huge number of patients who abandon this treatment due to this condition. Facultad de Ciencias Médicas Articulo Articulo http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 1-6
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Vitamin D
statins
Statin-Related Myopathy
spellingShingle Medicina
Vitamin D
statins
Statin-Related Myopathy
Mansur, José Luis
Statin Related Myopathy and Vitamin D
topic_facet Medicina
Vitamin D
statins
Statin-Related Myopathy
description Statins are usually safe and well tolerated drugs, very effective for cardiovascular prevention. The presence of myopathy, rare, but with different incidence in different reports, is one of the causes of abandonment of its use. It has begun to report association between decreased vitamin D levels and increased risk of myopathy, on the one hand, and reports where patients who stop statins consumption due to myalgia, with vitamin D deficiency, can tolerate these drugs once the vitamin is supplemented to values desirable Another factor clearly related to myopathy is the presence of polymorphisms in enzyme genes that metabolize or transport statins. As many patients with vitamin D deficiency do not have pain or are completely asymptomatic (with or without statins), we may consider it as a risk factor for developing myopathy due to statins (such as the simultaneous administration of drugs that are metabolized by the same cytochrome P450 pathway, or the presence of mentioned polymorphisms). In conclusion, the finding that having Vitamin D deficiency is associated with statin myopathy, or is a risk factor to develop it, opens new perspectives for a huge number of patients who abandon this treatment due to this condition.
format Articulo
Articulo
author Mansur, José Luis
author_facet Mansur, José Luis
author_sort Mansur, José Luis
title Statin Related Myopathy and Vitamin D
title_short Statin Related Myopathy and Vitamin D
title_full Statin Related Myopathy and Vitamin D
title_fullStr Statin Related Myopathy and Vitamin D
title_full_unstemmed Statin Related Myopathy and Vitamin D
title_sort statin related myopathy and vitamin d
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/151970
https://gratisoa.org/journals/index.php/ACEM/article/view/1382
work_keys_str_mv AT mansurjoseluis statinrelatedmyopathyandvitamind
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