Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints

Artificial pancreas (AP) systems for people with type 1 diabetes (T1DM) combine the use of a smart insulinpump with a Continuous Glucose Monitor (CGM) and a control algorithm to improve the regulation ofglycaemia. Based on the extensive clinical evidence provided by the main research groups in the a...

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Detalles Bibliográficos
Autores principales:	Fushimi, Emilia, Rosales, Nicolás, De Battista, Hernán, Garelli, Fabricio
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2018
Materias:	Ingeniería Electrónica Artificial pancreas Clinical trial Glucose control Sliding mode control Insulin-on-board
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/149290
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-149290
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ingeniería Electrónica Artificial pancreas Clinical trial Glucose control Sliding mode control Insulin-on-board
spellingShingle	Ingeniería Electrónica Artificial pancreas Clinical trial Glucose control Sliding mode control Insulin-on-board Fushimi, Emilia Rosales, Nicolás De Battista, Hernán Garelli, Fabricio Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints
topic_facet	Ingeniería Electrónica Artificial pancreas Clinical trial Glucose control Sliding mode control Insulin-on-board
description	Artificial pancreas (AP) systems for people with type 1 diabetes (T1DM) combine the use of a smart insulinpump with a Continuous Glucose Monitor (CGM) and a control algorithm to improve the regulation ofglycaemia. Based on the extensive clinical evidence provided by the main research groups in the area, ahybrid control algorithm combining insulin meal boluses and glucose feedback action has been recentlyapproved. However, this sort of algorithms should be refined especially during the postprandial period.In turn, fully closed-loop control strategies have to be further developed. In either case, intensive in vivovalidation is necessary to ensure the viability of the proposed strategy as an effective method to treatT1DM patients. In this paper, a safety layer called SAFE loop [1] is reformulated to be employed duringclinical trials in two different ways: the time enable mode to gradually activate the closed-loop controlafter an insulin meal bolus in hybrid configurations; and the amplitude enable mode to activate the fullclosed-loop control as long as the insulin infusion does not exceed the conventional therapy to a givenextent. The SAFE module decides the activation of the controller as a function of a constraint on the insulinon board (IOB). In the case of the Time Enable, this results in the use of a constant restriction on the IOB,whereas in the amplitude enable it results in the use of a time-varying IOB constraint. Both operationmodes are evaluated in silico using broadly accepted high-order models and the results contrasted withthe ones obtained without the SAFE protection.
format	Articulo Articulo
author	Fushimi, Emilia Rosales, Nicolás De Battista, Hernán Garelli, Fabricio
author_facet	Fushimi, Emilia Rosales, Nicolás De Battista, Hernán Garelli, Fabricio
author_sort	Fushimi, Emilia
title	Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints
title_short	Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints
title_full	Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints
title_fullStr	Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints
title_full_unstemmed	Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints
title_sort	artificial pancreas clinical trials: moving towards closed-loop control using insulin-on-board constraints
publishDate	2018
url	http://sedici.unlp.edu.ar/handle/10915/149290
work_keys_str_mv	AT fushimiemilia artificialpancreasclinicaltrialsmovingtowardsclosedloopcontrolusinginsulinonboardconstraints AT rosalesnicolas artificialpancreasclinicaltrialsmovingtowardsclosedloopcontrolusinginsulinonboardconstraints AT debattistahernan artificialpancreasclinicaltrialsmovingtowardsclosedloopcontrolusinginsulinonboardconstraints AT garellifabricio artificialpancreasclinicaltrialsmovingtowardsclosedloopcontrolusinginsulinonboardconstraints
bdutipo_str	Repositorios
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Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints

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