Ion channels in k562 human leukemic cells and the relation with the multidrug resistance

Enhanced proliferation, aberrant differentiation, and impaired ability to die are the prime reasons for abnormal tissue growth, which can eventually turn into uncontrolled expansion and invasion, characteristic of cancer. Ion channels contribute to virtually all basic cellular processes, including t...

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Autores principales: Assef, Yanina, Kotsias, Basilio A.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Ciencias Médicas
Ión
Fisiología
Células
Leucemia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/148577
https://pmr.safisiol.org.ar/issue/ion-channels-in-k562-human-leukemic-cells-and-the-relation-with-the-multidrug-resistance/
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-148577
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Ión
Fisiología
Células
Leucemia
spellingShingle Ciencias Médicas
Ión
Fisiología
Células
Leucemia
Assef, Yanina
Kotsias, Basilio A.
Ion channels in k562 human leukemic cells and the relation with the multidrug resistance
topic_facet Ciencias Médicas
Ión
Fisiología
Células
Leucemia
description Enhanced proliferation, aberrant differentiation, and impaired ability to die are the prime reasons for abnormal tissue growth, which can eventually turn into uncontrolled expansion and invasion, characteristic of cancer. Ion channels contribute to virtually all basic cellular processes, including those for maintaining tissue homeostasis as proliferation, differentiation, and apoptosis (1). Changes in cell volume are crucial events during both cell proliferation and apoptosis and thus on tumor development and growth (2). Cell proliferation depends on an increased cell volume and cell shrinkage is a characteristic of apoptosis. Potassium, calcium, chloride channels and others are abnormally expressed in the membrane of tumor cells. By the regulation of membrane voltage, cell volume, Ca2+ signaling, cytosolic pH and cell cycle, they can adjust the cell proliferation and apoptosis. The specific blockade of ion channels may not only allow the dissection of the channel role in distinct physiologic processes, but because of the implication of them in tumor development, it may also offer an opportunity for the treatment of cancer. However, many ion channels are structurally similar to one another, and it has been notoriously difficult to obtain specific blockers for any given channel, thus it is essential to generate more potent and specific inhibitors of ion channels before using them in human therapeutics.
format Articulo
Articulo
author Assef, Yanina
Kotsias, Basilio A.
author_facet Assef, Yanina
Kotsias, Basilio A.
author_sort Assef, Yanina
title Ion channels in k562 human leukemic cells and the relation with the multidrug resistance
title_short Ion channels in k562 human leukemic cells and the relation with the multidrug resistance
title_full Ion channels in k562 human leukemic cells and the relation with the multidrug resistance
title_fullStr Ion channels in k562 human leukemic cells and the relation with the multidrug resistance
title_full_unstemmed Ion channels in k562 human leukemic cells and the relation with the multidrug resistance
title_sort ion channels in k562 human leukemic cells and the relation with the multidrug resistance
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/148577
https://pmr.safisiol.org.ar/issue/ion-channels-in-k562-human-leukemic-cells-and-the-relation-with-the-multidrug-resistance/
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