NO· in the paracrine control of the proximal convoluted tubule of the rat

PCT is the main responsible for bulk reabsorption of solutes and volume in the nephron. Almost 80% of the glomerular filtrate is reabsorbed from the lumen of the PCT through the peritubular capillaries. Considering an individual of 70 Kg this amounts up to 140L of water and almost 0.5 Kg of Na+ reab...

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Autor principal: Amorena, Carlos
Formato: Articulo
Lenguaje:Inglés
Publicado: 2007
Materias:
Ciencias Médicas
PCT
Sodio
Fisiología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/148572
https://pmr.safisiol.org.ar/issue/no-in-the-paracrine-control-of-the-proximal-convoluted-tubule-of-the-rat/
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-148572
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
PCT
Sodio
Fisiología
spellingShingle Ciencias Médicas
PCT
Sodio
Fisiología
Amorena, Carlos
NO· in the paracrine control of the proximal convoluted tubule of the rat
topic_facet Ciencias Médicas
PCT
Sodio
Fisiología
description PCT is the main responsible for bulk reabsorption of solutes and volume in the nephron. Almost 80% of the glomerular filtrate is reabsorbed from the lumen of the PCT through the peritubular capillaries. Considering an individual of 70 Kg this amounts up to 140L of water and almost 0.5 Kg of Na+ reabsorbed per day; almost three times the total body water content and ten times the total body Na content. The whole process of Na+ reabsorption can be divided in three sequential steps: the first one driven mostly by the electrochemical gradient for sodium at the apical membrane, the second, which is pivotal and responsible for O2 consumption of the kidney, involves the activity of the Na+-K+ ATPase located at the basolateral membrane which extrudes Na+ out of the cytosol , and the third one, due to solvent drag, occurring through the endothelial cells of capillaries, consequence of the Starling’s equilibrium forces between the peritubular interstitium and the peritubular capillary lumen. Indeed, as a result of glomerular filtration the balance between oncotic pressure and hydrostatic pressure favors the net flow of volume from the interstitium through the capillary including the solutes present in the reabsorbed fluid.
format Articulo
Articulo
author Amorena, Carlos
author_facet Amorena, Carlos
author_sort Amorena, Carlos
title NO· in the paracrine control of the proximal convoluted tubule of the rat
title_short NO· in the paracrine control of the proximal convoluted tubule of the rat
title_full NO· in the paracrine control of the proximal convoluted tubule of the rat
title_fullStr NO· in the paracrine control of the proximal convoluted tubule of the rat
title_full_unstemmed NO· in the paracrine control of the proximal convoluted tubule of the rat
title_sort no· in the paracrine control of the proximal convoluted tubule of the rat
publishDate 2007
url http://sedici.unlp.edu.ar/handle/10915/148572
https://pmr.safisiol.org.ar/issue/no-in-the-paracrine-control-of-the-proximal-convoluted-tubule-of-the-rat/
work_keys_str_mv AT amorenacarlos nointheparacrinecontroloftheproximalconvolutedtubuleoftherat
bdutipo_str Repositorios
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