Bay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria

The effect of Bay K 8644 (a dihydropyridine Ca²⁺-channel activator), was examined on spontaneous and stimulus-evoked release of tritium from isolated rat atria prelabelled with [³H]-noradrenaline. Bay K8644 (3μmol/l) significantly increased atrial rate from 206±7 to 259±9 beats·min⁻¹ (P<0.05) and...

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Autores principales: Camilión de Hurtado, María Cristina, Gende, Oscar Alfredo, Cingolani, Horacio Eugenio
Formato: Articulo
Lenguaje:Inglés
Publicado: 1991
Materias:
Medicina
Bay K 8644
Rat atria
Tritium effiux
Adrenergic nerve endings
[³H]-noradrenaline
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/147269
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-147269
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Bay K 8644
Rat atria
Tritium effiux
Adrenergic nerve endings
[³H]-noradrenaline
spellingShingle Medicina
Bay K 8644
Rat atria
Tritium effiux
Adrenergic nerve endings
[³H]-noradrenaline
Camilión de Hurtado, María Cristina
Gende, Oscar Alfredo
Cingolani, Horacio Eugenio
Bay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria
topic_facet Medicina
Bay K 8644
Rat atria
Tritium effiux
Adrenergic nerve endings
[³H]-noradrenaline
description The effect of Bay K 8644 (a dihydropyridine Ca²⁺-channel activator), was examined on spontaneous and stimulus-evoked release of tritium from isolated rat atria prelabelled with [³H]-noradrenaline. Bay K8644 (3μmol/l) significantly increased atrial rate from 206±7 to 259±9 beats·min⁻¹ (P<0.05) and also tritium outflow (expressed as fractional rate of loss in min⁻¹ × 10³) from 6.49±0.35 to 8.61±0.74 (P<0.05). Neither the maximal rate nor the overflow of tritium induced by stimulation of sympathetic nerve terminals was changed by the compound. The increase in basal tritium outflow produced by Bay K 8644 was calcium-dependent. However, it could not be antagonized by nitrendipine. The overflow of tritium induced by Bay K 8644 consisted mainly of 3,4-dihydroxyphenylglycol ([³H]-DOPEG), indicating that the compound produces a leakage from the storage vesicles of sympathetic nerve terminals of the isolated rat atria.
format Articulo
Articulo
author Camilión de Hurtado, María Cristina
Gende, Oscar Alfredo
Cingolani, Horacio Eugenio
author_facet Camilión de Hurtado, María Cristina
Gende, Oscar Alfredo
Cingolani, Horacio Eugenio
author_sort Camilión de Hurtado, María Cristina
title Bay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria
title_short Bay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria
title_full Bay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria
title_fullStr Bay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria
title_full_unstemmed Bay K 8644 enhances the outflow of [³H]-noradrenaline and [³H]-DOPEG from isolated rat atria
title_sort bay k 8644 enhances the outflow of [³h]-noradrenaline and [³h]-dopeg from isolated rat atria
publishDate 1991
url http://sedici.unlp.edu.ar/handle/10915/147269
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