Role of sarcolemmal ATP-dependent K⁺ channels in cardiac ischemic injury
In the normoperfused heart, Ca²⁺ enters the myocardial cell through voltagedependent Ca²⁺ channels and is extruded through the sarcolemmal Ca²⁺ pump and the Na+/Ca²⁺ exchanger. During ischemia and early reperfusion, however, sarcoplasmic reticulum reuptake and sarcolemmal Ca²⁺ pump activities are im...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo Revision |
| Lenguaje: | Español |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/146976 https://pmr.safisiol.org.ar/wp-content/uploads/2022/09/vol1_n8_march.pdf |
| Aporte de: |
| id |
I19-R120-10915-146976 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Español |
| topic |
Ciencias Médicas Fisiología Ischemia Potassium |
| spellingShingle |
Ciencias Médicas Fisiología Ischemia Potassium Lascano, Elena C. Negroni, Jorge A. Role of sarcolemmal ATP-dependent K⁺ channels in cardiac ischemic injury |
| topic_facet |
Ciencias Médicas Fisiología Ischemia Potassium |
| description |
In the normoperfused heart, Ca²⁺ enters the myocardial cell through voltagedependent Ca²⁺ channels and is extruded through the sarcolemmal Ca²⁺ pump and the Na+/Ca²⁺ exchanger. During ischemia and early reperfusion, however, sarcoplasmic reticulum reuptake and sarcolemmal Ca²⁺ pump activities are impaired due to decreased ATP. In addition, owing to defective Na⁺-K⁺ pump performance and low pH favoring Na⁺ entry in exchange for H⁺ output through the Na⁺/H⁺ exchanger, the Na⁺/Ca²⁺ exchanger operates in its reverse mode incorporating Ca²⁺ to diminish increased intracellular Na⁺.
Thus, the resulting impaired Ca²⁺ balance produces Ca²⁺ overload and myocardial injury probably by activation of Ca²⁺-dependent proteases which can partially destroy contractile proteins leading to decreased responsiveness of contractile filaments to Ca²⁺ (18). This chain of ischemic events is in part counteracted by activation of ATP-dependent K⁺ (KATP) channels which by allowing earlier passive K⁺ output, shortens action potential duration and reduces the time during which Ca²⁺ can enter the cell. |
| format |
Articulo Revision |
| author |
Lascano, Elena C. Negroni, Jorge A. |
| author_facet |
Lascano, Elena C. Negroni, Jorge A. |
| author_sort |
Lascano, Elena C. |
| title |
Role of sarcolemmal ATP-dependent K⁺ channels in cardiac ischemic injury |
| title_short |
Role of sarcolemmal ATP-dependent K⁺ channels in cardiac ischemic injury |
| title_full |
Role of sarcolemmal ATP-dependent K⁺ channels in cardiac ischemic injury |
| title_fullStr |
Role of sarcolemmal ATP-dependent K⁺ channels in cardiac ischemic injury |
| title_full_unstemmed |
Role of sarcolemmal ATP-dependent K⁺ channels in cardiac ischemic injury |
| title_sort |
role of sarcolemmal atp-dependent k⁺ channels in cardiac ischemic injury |
| publishDate |
2006 |
| url |
http://sedici.unlp.edu.ar/handle/10915/146976 https://pmr.safisiol.org.ar/wp-content/uploads/2022/09/vol1_n8_march.pdf |
| work_keys_str_mv |
AT lascanoelenac roleofsarcolemmalatpdependentkchannelsincardiacischemicinjury AT negronijorgea roleofsarcolemmalatpdependentkchannelsincardiacischemicinjury |
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Repositorios |
| _version_ |
1764820460710658049 |