Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D

Advanced glycation end products (AGE) have been demonstrated to induce the osteogenic trans-differentiation of vascular smooth muscle cells (VSMC). Strontium ranelate (SR) is an anti-osteoporotic agent that has both anti-catabolic and anabolic actions on bone tissue. However, in the last years SR ha...

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Detalles Bibliográficos
Autores principales: Molinuevo, María Silvina, Fernández, Juan Manuel, Cortizo, Ana María, McCarthy, Antonio Desmond, Schurman, León, Sedlinsky, Claudia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/146213
Aporte de:
id I19-R120-10915-146213
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Advanced glycation end products
Vascular smooth muscle cells
Strontium ranelate
Osteoblasts
Vitamin D
spellingShingle Biología
Advanced glycation end products
Vascular smooth muscle cells
Strontium ranelate
Osteoblasts
Vitamin D
Molinuevo, María Silvina
Fernández, Juan Manuel
Cortizo, Ana María
McCarthy, Antonio Desmond
Schurman, León
Sedlinsky, Claudia
Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D
topic_facet Biología
Advanced glycation end products
Vascular smooth muscle cells
Strontium ranelate
Osteoblasts
Vitamin D
description Advanced glycation end products (AGE) have been demonstrated to induce the osteogenic trans-differentiation of vascular smooth muscle cells (VSMC). Strontium ranelate (SR) is an anti-osteoporotic agent that has both anti-catabolic and anabolic actions on bone tissue. However, in the last years SR has been associated with an increase of cardiovascular risk. We hypothesize that SR can increase the osteoblastic trans-differentiation of VSMC and the induction of extracellular calcifications, an effect that could be potentiated in the presence of AGE and inhibited by simultaneous administration of vitamin D. The present results of our in vitro experiments demonstrate that AGE and SR alone or in combination, stimulate L-type calcium channels, causing an increase in reactive oxygen species and activation of both ERK and NFkB, with the final effect of promoting the osteogenic shift of VSMC. Importantly, these in vitro effects of AGE and/or SR can be prevented by co-incubation with vitamin D.
format Articulo
Articulo
author Molinuevo, María Silvina
Fernández, Juan Manuel
Cortizo, Ana María
McCarthy, Antonio Desmond
Schurman, León
Sedlinsky, Claudia
author_facet Molinuevo, María Silvina
Fernández, Juan Manuel
Cortizo, Ana María
McCarthy, Antonio Desmond
Schurman, León
Sedlinsky, Claudia
author_sort Molinuevo, María Silvina
title Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D
title_short Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D
title_full Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D
title_fullStr Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D
title_full_unstemmed Advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin D
title_sort advanced glycation end products and strontium ranelate promote osteogenic differentiation of vascular smooth muscle cells in vitro: preventive role of vitamin d
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/146213
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