Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare

Motivation: Bacterial genomes are composed by a core and an accessory genome. The first composed of housekeeping and essential genes, while the second is composed, in its majority, of mobile genetic elements, including transposable elements (TEs). Insertion sequences (ISs), the smallest TEs, have an...

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Detalles Bibliográficos
Autores principales: Mogro, Ezequiel Gerardo, Ambrosis, Nicolás Martín, Lozano, Mauricio Javier
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Biología
insertion sequence
transposon
genomics
Group II introns
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/145890
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-145890
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
insertion sequence
transposon
genomics
Group II introns
spellingShingle Biología
insertion sequence
transposon
genomics
Group II introns
Mogro, Ezequiel Gerardo
Ambrosis, Nicolás Martín
Lozano, Mauricio Javier
Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare
topic_facet Biología
insertion sequence
transposon
genomics
Group II introns
description Motivation: Bacterial genomes are composed by a core and an accessory genome. The first composed of housekeeping and essential genes, while the second is composed, in its majority, of mobile genetic elements, including transposable elements (TEs). Insertion sequences (ISs), the smallest TEs, have an important role in genome evolution, and contribute to bacterial genome plasticity and adaptability. ISs can spread in a genome, presenting different locations in nearly related strains, and producing phenotypic variations. Few tools are available which can identify differentially located ISs (DLIS) on assembled genomes. Results: We developed ISCompare to profile IS mobilization events in related bacterial strains using complete or draft genome assemblies. ISCompare was validated using artificial genomes with simulated random IS insertions and real sequences, achieving the same or better results than other available tools, with the advantage that ISCompare can analyse multiple ISs at the same time and outputs a list of candidate DLIS. We think that ISCompare provides an easy and straightforward approach to look for differentially located ISs on bacterial genomes.
format Articulo
Articulo
author Mogro, Ezequiel Gerardo
Ambrosis, Nicolás Martín
Lozano, Mauricio Javier
author_facet Mogro, Ezequiel Gerardo
Ambrosis, Nicolás Martín
Lozano, Mauricio Javier
author_sort Mogro, Ezequiel Gerardo
title Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare
title_short Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare
title_full Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare
title_fullStr Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare
title_full_unstemmed Easy identification of insertion sequence mobilization events in related bacterial strains with ISCompare
title_sort easy identification of insertion sequence mobilization events in related bacterial strains with iscompare
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/145890
work_keys_str_mv AT mogroezequielgerardo easyidentificationofinsertionsequencemobilizationeventsinrelatedbacterialstrainswithiscompare
AT ambrosisnicolasmartin easyidentificationofinsertionsequencemobilizationeventsinrelatedbacterialstrainswithiscompare
AT lozanomauriciojavier easyidentificationofinsertionsequencemobilizationeventsinrelatedbacterialstrainswithiscompare
bdutipo_str Repositorios
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