Serum Protein Profile and Blood Cell Counts in Adult Toads Bufo Arenarum (Amphibia: Anura: Bufonidae) : Effects of Sublethal Lead Acetate

Lead is a multiple-source pollutant, well known for its toxicity, of great risk both for the environment and human health. The main target organs of lead are the hematopoietic, nervous, and renal systems; there are also reports in support of its impairment effects on the reproductive and immune syst...

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Autores principales: Chiesa, María Elena, Rosenberg, Carolina Elena, Fink, Nilda Esther, Salibian, Alfredo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2006
Materias:
Química
Ciencias Exactas
toxicity
human health
blood cells
lead acetate
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/142060
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-142060
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Ciencias Exactas
toxicity
human health
blood cells
lead acetate
spellingShingle Química
Ciencias Exactas
toxicity
human health
blood cells
lead acetate
Chiesa, María Elena
Rosenberg, Carolina Elena
Fink, Nilda Esther
Salibian, Alfredo
Serum Protein Profile and Blood Cell Counts in Adult Toads Bufo Arenarum (Amphibia: Anura: Bufonidae) : Effects of Sublethal Lead Acetate
topic_facet Química
Ciencias Exactas
toxicity
human health
blood cells
lead acetate
description Lead is a multiple-source pollutant, well known for its toxicity, of great risk both for the environment and human health. The main target organs of lead are the hematopoietic, nervous, and renal systems; there are also reports in support of its impairment effects on the reproductive and immune systems. It is well known that most of the metal is accumulated in the blood cells and that many of the deleterious effects are related to its circulating concentrations. These adverse effects have been described not only in humans but also in a number of other vertebrates such as fish and birds. The purpose of the present work was to evaluate the effects of weekly administration of sublethal Pb (as acetate, 50 mg ċ kg−1) during 6 weeks on the profile of the serum proteins and blood cell counts of the adult South American toad, Bufo arenarum (Anura: Bufonidae). The electrophoretic patterns of serum proteins pointed out the presence of four fractions; the metal provoked a significant decrease in both total proteins and albumin fraction; among the globulin fractions, the G3 resulted augmented. These findings may be related to the impact of lead on the toads’ hepatic cells and immune system. The number of total red blood cells (RBC) showed a tendency to decrease after the injections of the metal, whereas the number of white blood cells (WBC) increased significantly; the differential leukocyte counts showed a statistically significant increase in the absolute number and in the relative percentage of blast-like cells. The decrease in RBC was attributed to the negative impact of the metals on the hemoglobin synthesis. The increasing of the WBC counts may be interpreted as a consequence of the induction of proliferation of pluripotential hematopoietic cells.
format Articulo
Articulo
author Chiesa, María Elena
Rosenberg, Carolina Elena
Fink, Nilda Esther
Salibian, Alfredo
author_facet Chiesa, María Elena
Rosenberg, Carolina Elena
Fink, Nilda Esther
Salibian, Alfredo
author_sort Chiesa, María Elena
title Serum Protein Profile and Blood Cell Counts in Adult Toads Bufo Arenarum (Amphibia: Anura: Bufonidae) : Effects of Sublethal Lead Acetate
title_short Serum Protein Profile and Blood Cell Counts in Adult Toads Bufo Arenarum (Amphibia: Anura: Bufonidae) : Effects of Sublethal Lead Acetate
title_full Serum Protein Profile and Blood Cell Counts in Adult Toads Bufo Arenarum (Amphibia: Anura: Bufonidae) : Effects of Sublethal Lead Acetate
title_fullStr Serum Protein Profile and Blood Cell Counts in Adult Toads Bufo Arenarum (Amphibia: Anura: Bufonidae) : Effects of Sublethal Lead Acetate
title_full_unstemmed Serum Protein Profile and Blood Cell Counts in Adult Toads Bufo Arenarum (Amphibia: Anura: Bufonidae) : Effects of Sublethal Lead Acetate
title_sort serum protein profile and blood cell counts in adult toads bufo arenarum (amphibia: anura: bufonidae) : effects of sublethal lead acetate
publishDate 2006
url http://sedici.unlp.edu.ar/handle/10915/142060
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