Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces

A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca2+ modified mica surface...

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Autores principales: Pérez Enríquez, Darlin Johana, Dell'Arciprete, María Laura, Dittler, María Laura, Miñán, Alejandro Guillermo, Prieto, Eduardo Daniel, González, Mónica Cristina
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Física
Biología
Calcium phosphate nanoshells
Ca2+activation
surface interaction
carboxyl group
drug release
bacterial susceptibility
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/141364
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-141364
record_format dspace
spelling I19-R120-10915-1413642024-07-29T18:54:26Z http://sedici.unlp.edu.ar/handle/10915/141364 Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces Pérez Enríquez, Darlin Johana Dell'Arciprete, María Laura Dittler, María Laura Miñán, Alejandro Guillermo Prieto, Eduardo Daniel González, Mónica Cristina 2020-05-11 2022-08-31T16:26:20Z en Física Biología Calcium phosphate nanoshells Ca2+activation surface interaction carboxyl group drug release bacterial susceptibility A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca2+ modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca2+-activated CaP nanoshell accumulation and drug release is proposed and discussed. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf 7541-7551
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Física
Biología
Calcium phosphate nanoshells
Ca2+activation
surface interaction
carboxyl group
drug release
bacterial susceptibility
spellingShingle Física
Biología
Calcium phosphate nanoshells
Ca2+activation
surface interaction
carboxyl group
drug release
bacterial susceptibility
Pérez Enríquez, Darlin Johana
Dell'Arciprete, María Laura
Dittler, María Laura
Miñán, Alejandro Guillermo
Prieto, Eduardo Daniel
González, Mónica Cristina
Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
topic_facet Física
Biología
Calcium phosphate nanoshells
Ca2+activation
surface interaction
carboxyl group
drug release
bacterial susceptibility
description A highly selective nanocarrier for targeted drug transport and delivery to calcium-containing surfaces, as a bone mineral matrix, is described. The nanocarrier, a calcium phosphate (CaP) nanoshell, is capable of interacting with calcium ions contained in enriched surfaces (Ca2+ modified mica surface, hydroxyapatite nanoparticle (Ap) films on glass, and Ap modified 45S5® bioactive glass-based scaffolds) with the consequent disruption of the inorganic structure and release of (bio) molecules contained in the interior. The antibiotic Levofloxacin (LX) was used as a model drug for encapsulation and drug release studies which allowed monitoring by fluorescence spectroscopic methods. The accumulation and disruption of CaP nanoshells triggered by calcium ions over surfaces were followed by microscopy techniques such as SEM, AFM, and fluorescence microscopy. Bacterial susceptibility and time killing assays demonstrated the bactericidal potential of the nanoshells containing LX. A mechanism for the Ca2+-activated CaP nanoshell accumulation and drug release is proposed and discussed.
format Articulo
Articulo
author Pérez Enríquez, Darlin Johana
Dell'Arciprete, María Laura
Dittler, María Laura
Miñán, Alejandro Guillermo
Prieto, Eduardo Daniel
González, Mónica Cristina
author_facet Pérez Enríquez, Darlin Johana
Dell'Arciprete, María Laura
Dittler, María Laura
Miñán, Alejandro Guillermo
Prieto, Eduardo Daniel
González, Mónica Cristina
author_sort Pérez Enríquez, Darlin Johana
title Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_short Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_full Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_fullStr Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_full_unstemmed Amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to Ca2+-enriched surfaces
title_sort amorphous calcium organophosphate nanoshells as potential carriers for drug delivery to ca2+-enriched surfaces
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/141364
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AT gonzalezmonicacristina amorphouscalciumorganophosphatenanoshellsaspotentialcarriersfordrugdeliverytoca2enrichedsurfaces
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