Calcium triggered arrhythmias and the goldilocks’ principle

Beyond the importance of calcium cycling on cardiac contractile function, calcium can also affect membrane currents and lead to arrhythmias. In this revision we will discuss how the balance between release and reuptake of calcium from and to the sarcoplasmic reticulum affects the probability of arrh...

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Detalles Bibliográficos
Autores principales: Valverde, Carlos Alfredo, Cely Ortiz, Diana Catalina Alejandra, Gonano, Luis Alberto, Lascano, Elena Catalina, Mattiazzi, Alicia Ramona
Formato: Articulo
Lenguaje:Inglés
Publicado: 2022
Materias:
Ciencias Médicas
Heart
Arrhythmias
Calcium
Sarcoplasmic Reticulum
RyR2
PLN
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/140985
https://pmr.safisiol.org.ar/wp-content/uploads/2022/06/Vol-15-numero-3-2022-otro.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-140985
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Heart
Arrhythmias
Calcium
Sarcoplasmic Reticulum
RyR2
PLN
spellingShingle Ciencias Médicas
Heart
Arrhythmias
Calcium
Sarcoplasmic Reticulum
RyR2
PLN
Valverde, Carlos Alfredo
Cely Ortiz, Diana Catalina Alejandra
Gonano, Luis Alberto
Lascano, Elena Catalina
Mattiazzi, Alicia Ramona
Calcium triggered arrhythmias and the goldilocks’ principle
topic_facet Ciencias Médicas
Heart
Arrhythmias
Calcium
Sarcoplasmic Reticulum
RyR2
PLN
description Beyond the importance of calcium cycling on cardiac contractile function, calcium can also affect membrane currents and lead to arrhythmias. In this revision we will discuss how the balance between release and reuptake of calcium from and to the sarcoplasmic reticulum affects the probability of arrhythmias. A mathematical human cardiomyocyte model that can simulate increasing RyR2 open probabilities (Po) along with high or low SERCA2A mediated reuptake velocities showed that arrhythmias occur in an intermediate physiological zone for both RyR2 Po and reuptake velocity. These results allow to make a parallelism with the “goldilocks and the tree bears” story in which she is looking to drink a cup of porridge with an intermediate optimal temperature. Along the text we explain how the Goldilocks principle is fulfilled in different well-known experimental situations.
format Articulo
Articulo
author Valverde, Carlos Alfredo
Cely Ortiz, Diana Catalina Alejandra
Gonano, Luis Alberto
Lascano, Elena Catalina
Mattiazzi, Alicia Ramona
author_facet Valverde, Carlos Alfredo
Cely Ortiz, Diana Catalina Alejandra
Gonano, Luis Alberto
Lascano, Elena Catalina
Mattiazzi, Alicia Ramona
author_sort Valverde, Carlos Alfredo
title Calcium triggered arrhythmias and the goldilocks’ principle
title_short Calcium triggered arrhythmias and the goldilocks’ principle
title_full Calcium triggered arrhythmias and the goldilocks’ principle
title_fullStr Calcium triggered arrhythmias and the goldilocks’ principle
title_full_unstemmed Calcium triggered arrhythmias and the goldilocks’ principle
title_sort calcium triggered arrhythmias and the goldilocks’ principle
publishDate 2022
url http://sedici.unlp.edu.ar/handle/10915/140985
https://pmr.safisiol.org.ar/wp-content/uploads/2022/06/Vol-15-numero-3-2022-otro.pdf
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AT lascanoelenacatalina calciumtriggeredarrhythmiasandthegoldilocksprinciple
AT mattiazzialiciaramona calciumtriggeredarrhythmiasandthegoldilocksprinciple
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