The action of insulin and dibutyryl cyclic AMP on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in HTC cells

Incubation of HTC cells (7288 C) with 114C-α-linolenic acid in Swim's 77 medium during 24 hours converted the fatty acid to octadeca-6,9,12,15-tetraenoic acid, eicosa-11,14,17-trienoic acid, eicosa-8,11,14,17-tetraenoic acid, eicosa-5,11,14,17-tetraenoic acid, eicosa-5,8,11,14,17-pentaenoic aci...

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Detalles Bibliográficos
Autores principales: Tacconi de Alaniz, María Josefa, Tacconi de Gómez Dumm, Irma Nelva, Brenner, Rodolfo Roberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 1976
Materias:
Medicina
Bioquímica
HTC cells
a-linolenic acid
A6-desaturation
insulin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/140246
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-140246
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Bioquímica
HTC cells
a-linolenic acid
A6-desaturation
insulin
spellingShingle Medicina
Bioquímica
HTC cells
a-linolenic acid
A6-desaturation
insulin
Tacconi de Alaniz, María Josefa
Tacconi de Gómez Dumm, Irma Nelva
Brenner, Rodolfo Roberto
The action of insulin and dibutyryl cyclic AMP on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in HTC cells
topic_facet Medicina
Bioquímica
HTC cells
a-linolenic acid
A6-desaturation
insulin
description Incubation of HTC cells (7288 C) with 114C-α-linolenic acid in Swim's 77 medium during 24 hours converted the fatty acid to octadeca-6,9,12,15-tetraenoic acid, eicosa-11,14,17-trienoic acid, eicosa-8,11,14,17-tetraenoic acid, eicosa-5,11,14,17-tetraenoic acid, eicosa-5,8,11,14,17-pentaenoic acid and unsaturated acids of 22 carbons. The existence of two pathways was recognized: one initiated by a Δ6-desaturation and the other by an elongation ofα-linolenic acid. Incubation of the cells with insulin and dibutyryl cyclic AMP modified both pathways in different ways. HTC cells were sensitive to insulin which enhanced the de-saturating route increasing eicosapentaenoic acid synthesis and depressed the elongating route decreasing eicosatrienoic acid. In an opposite way, dibutyryl cyclic AMP decreased eicosapentaenoic acid synthesis and increased eicosatrienoic acid.
format Articulo
Articulo
author Tacconi de Alaniz, María Josefa
Tacconi de Gómez Dumm, Irma Nelva
Brenner, Rodolfo Roberto
author_facet Tacconi de Alaniz, María Josefa
Tacconi de Gómez Dumm, Irma Nelva
Brenner, Rodolfo Roberto
author_sort Tacconi de Alaniz, María Josefa
title The action of insulin and dibutyryl cyclic AMP on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in HTC cells
title_short The action of insulin and dibutyryl cyclic AMP on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in HTC cells
title_full The action of insulin and dibutyryl cyclic AMP on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in HTC cells
title_fullStr The action of insulin and dibutyryl cyclic AMP on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in HTC cells
title_full_unstemmed The action of insulin and dibutyryl cyclic AMP on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in HTC cells
title_sort action of insulin and dibutyryl cyclic amp on the biosynthesis of polyunsaturated acids ofα-linolenic acid family in htc cells
publishDate 1976
url http://sedici.unlp.edu.ar/handle/10915/140246
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