Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes

The effect of glucagon, dibutyryl cyclic adenosine 3′,5′-monophosphate, and epinephrine on the biosynthesis of polyunsaturated fatty acids of the linoleic acid family was studied. The incubations were performed with rat liver microsomes and labeled linoleic acid under desaturating and elongating con...

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Detalles Bibliográficos
Autores principales: Tacconi de Gómez Dumm, Irma Nelva, Tacconi de Alaniz, María Josefa, Brenner, Rodolfo Roberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 1976
Materias:
Medicina
Linoleic Acid
Theophylline
Glucagon
Desaturation Activity
Purina Chow
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/140098
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-140098
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Linoleic Acid
Theophylline
Glucagon
Desaturation Activity
Purina Chow
spellingShingle Medicina
Linoleic Acid
Theophylline
Glucagon
Desaturation Activity
Purina Chow
Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes
topic_facet Medicina
Linoleic Acid
Theophylline
Glucagon
Desaturation Activity
Purina Chow
description The effect of glucagon, dibutyryl cyclic adenosine 3′,5′-monophosphate, and epinephrine on the biosynthesis of polyunsaturated fatty acids of the linoleic acid family was studied. The incubations were performed with rat liver microsomes and labeled linoleic acid under desaturating and elongating conditions. Under desaturating conditions, linoleic acid was converted to γ-linolenic acid, whereas under elongating conditions it was converted to 20∶2ω6. Glucagon, dibutyryl cyclic AMP, and epinephrine decreased the oxidative desaturation of linoleic acid to γ-linolenic acid while the elongating reaction was not modified in the experimental conditions tested. Consequently, the results support the hypothesis that the oxidative desaturation of linoleic acid to γ-linolenic acid is the main controllable step in the biosynthesis of polyunsaturated fatty acids of the linoleic acid family in the microsomes.
format Articulo
Articulo
author Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author_facet Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author_sort Tacconi de Gómez Dumm, Irma Nelva
title Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes
title_short Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes
title_full Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes
title_fullStr Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes
title_full_unstemmed Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes
title_sort comparative effect of glucagon, dibutyryl cyclic amp, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes
publishDate 1976
url http://sedici.unlp.edu.ar/handle/10915/140098
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