TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk

Although the implication of genetic factors in cervical cancer development remains to be elucidated, accumulative epidemiological evidence suggests that polymorphisms of cytokine genes may be involved in the etiology of cervical carcinoma. Tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-1...

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Autores principales: Barbisan, Gisela, Pérez, Luis Orlando, Contreras, Anahí, Golijow, Carlos Daniel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Biología
Cervical cancer
IL-10
TNF-α
Polymorphisms
HPV
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139541
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-139541
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Cervical cancer
IL-10
TNF-α
Polymorphisms
HPV
spellingShingle Biología
Cervical cancer
IL-10
TNF-α
Polymorphisms
HPV
Barbisan, Gisela
Pérez, Luis Orlando
Contreras, Anahí
Golijow, Carlos Daniel
TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk
topic_facet Biología
Cervical cancer
IL-10
TNF-α
Polymorphisms
HPV
description Although the implication of genetic factors in cervical cancer development remains to be elucidated, accumulative epidemiological evidence suggests that polymorphisms of cytokine genes may be involved in the etiology of cervical carcinoma. Tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) are two multifunctional cytokines implicated in inflammation, immunity, and cellular organization, and were proposed to play important roles in cancer biology. In order to determine whether IL-10 -1082 (G/A) and TNF-α -238 (G/A) and -308 (G/A) polymorphisms are associated with susceptibility to cervical cancer, a case-control study of 122 cancer patients and 176 healthy controls was conducted. Cervical samples were genotyped for both TNF-α polymorphisms by PCR-RFLP assay. SNP-1082 from IL-10 gene was genotyped using pyrosequencing technology. The association between cervical cancer risk and the studied SNPs was evaluated by logistic regression. Under univariate analysis, none of these polymorphisms appeared associated with susceptibility of cervical cancer development or HPV infection. However, individuals carrying heterozygous genotype for TNF-α -238 polymorphism seem to be at lower risk for cervical cancer development, with borderline significance (OR = 0.42, P = 0.069), as well as those carrying heterozygous genotypes for IL-10 and TNF-α -238 (OR = 0.40, P = 0.08). In conclusion, these results suggest a potential effect of TNF-α -238 G/A in the reduction of cervical cancer risk in Argentine women, but not TNF-α -308 or IL-10. Larger studies are needed to fully understand the genetic predisposition for the development of cervical cancer.
format Articulo
Articulo
author Barbisan, Gisela
Pérez, Luis Orlando
Contreras, Anahí
Golijow, Carlos Daniel
author_facet Barbisan, Gisela
Pérez, Luis Orlando
Contreras, Anahí
Golijow, Carlos Daniel
author_sort Barbisan, Gisela
title TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk
title_short TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk
title_full TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk
title_fullStr TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk
title_full_unstemmed TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk
title_sort tnf-α and il-10 promoter polymorphisms, hpv infection, and cervical cancer risk
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/139541
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