Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis

The production of Bordetella pertussis extracytoplasmic filamentous haemagglutinin (FHA) and pertussis toxin (PT) in a bioreactor under stirring conditions was studied in order to investigate the effect of hydromechanical forces on yields of both antigens. It was shown that FHA loses its haemaggluti...

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Detalles Bibliográficos
Autores principales: Rodríguez, María Eugenia, Samo, Analia L., Hozbor, Daniela Flavia, Yantorno, Osvaldo Miguel
Formato: Articulo
Lenguaje:Inglés
Publicado: 1993
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139310
Aporte de:
id I19-R120-10915-139310
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Física
Bordetella pertussis
Filamentous haemagglutinin
Pertussis toxin
Production
Shear stress
Bioreactor
spellingShingle Química
Física
Bordetella pertussis
Filamentous haemagglutinin
Pertussis toxin
Production
Shear stress
Bioreactor
Rodríguez, María Eugenia
Samo, Analia L.
Hozbor, Daniela Flavia
Yantorno, Osvaldo Miguel
Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis
topic_facet Química
Física
Bordetella pertussis
Filamentous haemagglutinin
Pertussis toxin
Production
Shear stress
Bioreactor
description The production of Bordetella pertussis extracytoplasmic filamentous haemagglutinin (FHA) and pertussis toxin (PT) in a bioreactor under stirring conditions was studied in order to investigate the effect of hydromechanical forces on yields of both antigens. It was shown that FHA loses its haemagglutinin activity when the power transmitted by the agitator and the aerator per unit volume increases, whereas PT production is not affected. The loss of FHA activity can be explained by the action of shear forces on the filamentous structure of this antigen.
format Articulo
Articulo
author Rodríguez, María Eugenia
Samo, Analia L.
Hozbor, Daniela Flavia
Yantorno, Osvaldo Miguel
author_facet Rodríguez, María Eugenia
Samo, Analia L.
Hozbor, Daniela Flavia
Yantorno, Osvaldo Miguel
author_sort Rodríguez, María Eugenia
title Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis
title_short Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis
title_full Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis
title_fullStr Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis
title_full_unstemmed Effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of Bordetella pertussis
title_sort effect of hydromechanical forces on the production of filamentous haemagglutinin and pertussis toxin of bordetella pertussis
publishDate 1993
url http://sedici.unlp.edu.ar/handle/10915/139310
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