4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles

Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nanoagents that can be removed from the body after use remains thus a...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Torresan, Veronica, Forrer, Daniel, Guadagnini, Andrea, Badocco, Denis, Pastore, Paolo, Casarin, Maurizio, Selloni, Annabella, Coral, D. F., Ceolín, Marcelo Raúl, Fernández van Raap, Marcela Beatriz, Busato, Alice, Marzola, Pasquina, Spinelli, Antonello E., Amendola, Vincenzo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Física
Química
Au nanoparticles
Fe nanoparticles
alloys
nanomedicine
degradable materials
CT
MRI
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139039
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-139039
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Física
Química
Au nanoparticles
Fe nanoparticles
alloys
nanomedicine
degradable materials
CT
MRI
spellingShingle Física
Química
Au nanoparticles
Fe nanoparticles
alloys
nanomedicine
degradable materials
CT
MRI
Torresan, Veronica
Forrer, Daniel
Guadagnini, Andrea
Badocco, Denis
Pastore, Paolo
Casarin, Maurizio
Selloni, Annabella
Coral, D. F.
Ceolín, Marcelo Raúl
Fernández van Raap, Marcela Beatriz
Busato, Alice
Marzola, Pasquina
Spinelli, Antonello E.
Amendola, Vincenzo
4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles
topic_facet Física
Química
Au nanoparticles
Fe nanoparticles
alloys
nanomedicine
degradable materials
CT
MRI
description Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nanoagents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that nonequilibrium gold–iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au–Fe solid solutions can exhibit self-degradation in an aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that nonequilibrium Au–Fe nanoalloys have a 4D behavior, that is, the ability to change shape, size, and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests show the potential of these transformable Au–Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed X-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au–Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.
format Articulo
Articulo
author Torresan, Veronica
Forrer, Daniel
Guadagnini, Andrea
Badocco, Denis
Pastore, Paolo
Casarin, Maurizio
Selloni, Annabella
Coral, D. F.
Ceolín, Marcelo Raúl
Fernández van Raap, Marcela Beatriz
Busato, Alice
Marzola, Pasquina
Spinelli, Antonello E.
Amendola, Vincenzo
author_facet Torresan, Veronica
Forrer, Daniel
Guadagnini, Andrea
Badocco, Denis
Pastore, Paolo
Casarin, Maurizio
Selloni, Annabella
Coral, D. F.
Ceolín, Marcelo Raúl
Fernández van Raap, Marcela Beatriz
Busato, Alice
Marzola, Pasquina
Spinelli, Antonello E.
Amendola, Vincenzo
author_sort Torresan, Veronica
title 4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles
title_short 4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles
title_full 4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles
title_fullStr 4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles
title_full_unstemmed 4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles
title_sort 4d multimodal nanomedicines made of nonequilibrium au-fe alloy nanoparticles
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/139039
work_keys_str_mv AT torresanveronica 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT forrerdaniel 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT guadagniniandrea 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT badoccodenis 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT pastorepaolo 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT casarinmaurizio 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT selloniannabella 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT coraldf 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT ceolinmarceloraul 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT fernandezvanraapmarcelabeatriz 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT busatoalice 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT marzolapasquina 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT spinelliantonelloe 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
AT amendolavincenzo 4dmultimodalnanomedicinesmadeofnonequilibriumaufealloynanoparticles
bdutipo_str Repositorios
_version_ 1764820456919007234

Ejemplares similares