Effect of catecholamines and β-blockers on linoleic acid desaturation activity

The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to gamma-linolenic acid. The effect of epinephri...

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Autores principales: Tacconi de Gómez Dumm, Irma Nelva, Tacconi de Alaniz, María Josefa, Brenner, Rodolfo Roberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 1978
Materias:
Medicina
Bioquímica
blocking agent
linoleic acid
rat liver
hormone treatment
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/139001
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-139001
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Bioquímica
blocking agent
linoleic acid
rat liver
hormone treatment
spellingShingle Medicina
Bioquímica
blocking agent
linoleic acid
rat liver
hormone treatment
Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
Effect of catecholamines and β-blockers on linoleic acid desaturation activity
topic_facet Medicina
Bioquímica
blocking agent
linoleic acid
rat liver
hormone treatment
description The effect of catecholamines and adrenergic blocking agents on the oxidative desaturation of linoleic acid in rat liver microsomes was studied. Epinephrine (1 mg/kg/body weight) produced a significant decrease on the conversion of [1-14C]linoleic acid to gamma-linolenic acid. The effect of epinephrine was blocked by single injections of the beta blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment. Isoproterenol (100 microgram/kg body weight) produced a significant decrease on the activity of the linoleyl-CoA desaturase. The effect of the catecholamines was postulated to be mediated through beta receptors by an enhancement of the intracellular levels of cyclic AMP.
format Articulo
Articulo
author Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author_facet Tacconi de Gómez Dumm, Irma Nelva
Tacconi de Alaniz, María Josefa
Brenner, Rodolfo Roberto
author_sort Tacconi de Gómez Dumm, Irma Nelva
title Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_short Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_full Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_fullStr Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_full_unstemmed Effect of catecholamines and β-blockers on linoleic acid desaturation activity
title_sort effect of catecholamines and β-blockers on linoleic acid desaturation activity
publishDate 1978
url http://sedici.unlp.edu.ar/handle/10915/139001
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AT brennerrodolforoberto effectofcatecholaminesandbblockersonlinoleicaciddesaturationactivity
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