The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels

In vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared...

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Autores principales: Rinaldi, Gustavo, Cingolani, Horacio Eugenio
Formato: Articulo
Lenguaje:Inglés
Publicado: 1983
Materias:
Ciencias Médicas
Coronary arteries
Molsidomine
Cyclic guanosine monophosphate
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138345
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-138345
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Coronary arteries
Molsidomine
Cyclic guanosine monophosphate
spellingShingle Ciencias Médicas
Coronary arteries
Molsidomine
Cyclic guanosine monophosphate
Rinaldi, Gustavo
Cingolani, Horacio Eugenio
The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
topic_facet Ciencias Médicas
Coronary arteries
Molsidomine
Cyclic guanosine monophosphate
description In vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared with those of a classic vasodilator, nitroglycerin (NTG). At equimolar doses (10(-6)M) SIN-1 exerted greater relaxant effect than NTG (80 +/- 2% and 60 +/- 5%, respectively) in spite of the fact that it produced less of an increase in cyclic guanosine monophosphate (cGMP) levels. cGMP levels fell rapidly after they peaked, but relaxation was maintained. cGMP elevation preceded the induction of relaxation by NTG but not that induced by SIN-1. Relaxation occurred faster after NTG than after SIN-1. Since SIN-1 has a greater relaxant effect than NTG in spite of the fact that SIN-1 induces less of an increase in cGMP levels and the fact that the peak elevation does not precede the onset of relaxation, the causal nexus between GMP level elevation and relaxation effect after sydnonimines should be challenged.
format Articulo
Articulo
author Rinaldi, Gustavo
Cingolani, Horacio Eugenio
author_facet Rinaldi, Gustavo
Cingolani, Horacio Eugenio
author_sort Rinaldi, Gustavo
title The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_short The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_full The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_fullStr The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_full_unstemmed The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_sort effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
publishDate 1983
url http://sedici.unlp.edu.ar/handle/10915/138345
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