Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis

Experimental infection of mice with foot-and-mouth disease virus (FMDV) induces a necrotizing pancreatitis of the exocrinar portion of the organ. The lesions are characterized by vascular congestion, edema and interstitial polymorphonuclear leukocyte (PMN) infiltrates. When infected mice were treate...

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Detalles Bibliográficos
Autores principales: Portiansky, Enrique Leo, González, Pedro Horacio
Formato: Articulo
Lenguaje:Inglés
Publicado: 1995
Materias:
Ciencias Médicas
Veterinaria
foot-and-mouth disease
lidocaine
pancreatitis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137861
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-137861
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Veterinaria
foot-and-mouth disease
lidocaine
pancreatitis
spellingShingle Ciencias Médicas
Veterinaria
foot-and-mouth disease
lidocaine
pancreatitis
Portiansky, Enrique Leo
González, Pedro Horacio
Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
topic_facet Ciencias Médicas
Veterinaria
foot-and-mouth disease
lidocaine
pancreatitis
description Experimental infection of mice with foot-and-mouth disease virus (FMDV) induces a necrotizing pancreatitis of the exocrinar portion of the organ. The lesions are characterized by vascular congestion, edema and interstitial polymorphonuclear leukocyte (PMN) infiltrates. When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed. Even though lidocaine could interfere with FMDV post-replicative cytolytic mechanisms, it appears that protection against pancreatic necrosis is by attenuation of PMN presentation in the infected tissue.
format Articulo
Articulo
author Portiansky, Enrique Leo
González, Pedro Horacio
author_facet Portiansky, Enrique Leo
González, Pedro Horacio
author_sort Portiansky, Enrique Leo
title Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_short Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_full Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_fullStr Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_full_unstemmed Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
title_sort protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis
publishDate 1995
url http://sedici.unlp.edu.ar/handle/10915/137861
work_keys_str_mv AT portianskyenriqueleo protectiveeffectoflidocaineintheexperimentalfootandmouthdiseasepancreatitis
AT gonzalezpedrohoracio protectiveeffectoflidocaineintheexperimentalfootandmouthdiseasepancreatitis
bdutipo_str Repositorios
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