Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver

Circadian variations in DNA synthesis after tritiated thymidine and autoradiography, mitotic activity with the Colcemid method, and cell size, represented inversely by the number of cells per microscopic field, are reported for the hepatocyte population of the young immature growing liver of the mal...

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Autores principales: Echave Llanos, Julián Miguel, Aloisso, M. D., Souto, M., Balduzzi, Roberto Ángel, Surur, José Miguel
Formato: Articulo
Lenguaje:Inglés
Publicado: 1971
Materias:
Ciencias Médicas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137746
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-137746
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
spellingShingle Ciencias Médicas
Echave Llanos, Julián Miguel
Aloisso, M. D.
Souto, M.
Balduzzi, Roberto Ángel
Surur, José Miguel
Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver
topic_facet Ciencias Médicas
description Circadian variations in DNA synthesis after tritiated thymidine and autoradiography, mitotic activity with the Colcemid method, and cell size, represented inversely by the number of cells per microscopic field, are reported for the hepatocyte population of the young immature growing liver of the male mouse. The peak of DNA synthesis is at 04:00 hours and that of mitotic activity at 12:00 hours. The 8-hour interval between the two peaks is considered, in agreement with other authors, a good estimation of the lag period between DNA synthesis and the initiation of mitotic activity. The minimum cell number per microscopic field, which is considered to correspond to the maximum cell size, coincides with the starting of the circadian mitotic wave. The significance of this coincidence and the relationships of the circadian curves of the parameters controlled with the feeding pattern and food consummatory curve of standardized mice, are discussed.
format Articulo
Articulo
author Echave Llanos, Julián Miguel
Aloisso, M. D.
Souto, M.
Balduzzi, Roberto Ángel
Surur, José Miguel
author_facet Echave Llanos, Julián Miguel
Aloisso, M. D.
Souto, M.
Balduzzi, Roberto Ángel
Surur, José Miguel
author_sort Echave Llanos, Julián Miguel
title Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver
title_short Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver
title_full Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver
title_fullStr Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver
title_full_unstemmed Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver
title_sort circadian variations of dna synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver
publishDate 1971
url http://sedici.unlp.edu.ar/handle/10915/137746
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