Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes

The coordination compound of the antihypertensive ligand irbesartan (irb) with copper(II) (CuIrb) was synthesized and characterized by FTIR, FT-Raman, UV–visible, reflectance and EPR spectroscopies. Experimental evidence allowed the implementation of structural and vibrational studies by theoretical...

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Detalles Bibliográficos
Autores principales:	Islas, María Soledad, Luengo, Alicia, Franca, Carlos Alberto, Griera Merino, Mercedes, Calleros, Laura, Rodríguez-Puyol, Manuel, Lezama, Luis, Ferrer, Evelina Gloria, Williams, Patricia Ana María
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Química Irbesartan Copper(II) complex Antioxidant Antihypertensive Cytotoxicity
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/134050
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-134050
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Irbesartan Copper(II) complex Antioxidant Antihypertensive Cytotoxicity
spellingShingle	Química Irbesartan Copper(II) complex Antioxidant Antihypertensive Cytotoxicity Islas, María Soledad Luengo, Alicia Franca, Carlos Alberto Griera Merino, Mercedes Calleros, Laura Rodríguez-Puyol, Manuel Lezama, Luis Ferrer, Evelina Gloria Williams, Patricia Ana María Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
topic_facet	Química Irbesartan Copper(II) complex Antioxidant Antihypertensive Cytotoxicity
description	The coordination compound of the antihypertensive ligand irbesartan (irb) with copper(II) (CuIrb) was synthesized and characterized by FTIR, FT-Raman, UV–visible, reflectance and EPR spectroscopies. Experimental evidence allowed the implementation of structural and vibrational studies by theoretical calculations made in the light of the density functional theory (DFT). This compound was designed to induce structural modifications on the ligand. No antioxidant effects were displayed by both compounds, though CuIrb behaved as a weak 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·) scavenger (IC₅₀ = 425 μM). The measurements of the contractile capacity on human mesangial cell lines showed that CuIrb improved the antihypertensive effects of the parent medication. In vitro cell growth inhibition against prostate cancer cell lines (LNCaP and DU 145) was measured for CuIrb, irbesartan and copper(II). These cell lines have been selected since the angiotensin II type 1 (AT1) receptor (that was blocked by the angiotensin receptor blockers, ARB) has been identified in them. The complex exerted anticancer behavior (at 100 μM) improving the activity of the ligand. Flow cytometry determinations were used to determine late apoptotic mechanisms of cell death.
format	Articulo Articulo
author	Islas, María Soledad Luengo, Alicia Franca, Carlos Alberto Griera Merino, Mercedes Calleros, Laura Rodríguez-Puyol, Manuel Lezama, Luis Ferrer, Evelina Gloria Williams, Patricia Ana María
author_facet	Islas, María Soledad Luengo, Alicia Franca, Carlos Alberto Griera Merino, Mercedes Calleros, Laura Rodríguez-Puyol, Manuel Lezama, Luis Ferrer, Evelina Gloria Williams, Patricia Ana María
author_sort	Islas, María Soledad
title	Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
title_short	Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
title_full	Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
title_fullStr	Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
title_full_unstemmed	Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
title_sort	experimental and dft characterization, antioxidant and anticancer activities of a cu(ii)–irbesartan complex: structure–antihypertensive activity relationships in cu(ii)–sartan complexes
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/134050
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Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes

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