Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<...
Guardado en:
Autores principales: | , , , , , , , , |
---|---|
Formato: | Articulo |
Lenguaje: | Inglés |
Publicado: |
2009
|
Materias: | |
Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/133155 |
Aporte de: |
id |
I19-R120-10915-133155 |
---|---|
record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Química Methimazole Copper Biometals Grave’s disease EPR FTIR UV-visible ALP inhibition |
spellingShingle |
Química Methimazole Copper Biometals Grave’s disease EPR FTIR UV-visible ALP inhibition Urquiza, Nora M. Manca, Silvia G. Moyano, María Alejandra Dellmans, Raquel Arrieta Lezama, Luis Rojo, Teófilo Naso, Luciana Gissella Williams, Patricia Ana María Ferrer, Evelina Gloria Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
topic_facet |
Química Methimazole Copper Biometals Grave’s disease EPR FTIR UV-visible ALP inhibition |
description |
Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated. |
format |
Articulo Articulo |
author |
Urquiza, Nora M. Manca, Silvia G. Moyano, María Alejandra Dellmans, Raquel Arrieta Lezama, Luis Rojo, Teófilo Naso, Luciana Gissella Williams, Patricia Ana María Ferrer, Evelina Gloria |
author_facet |
Urquiza, Nora M. Manca, Silvia G. Moyano, María Alejandra Dellmans, Raquel Arrieta Lezama, Luis Rojo, Teófilo Naso, Luciana Gissella Williams, Patricia Ana María Ferrer, Evelina Gloria |
author_sort |
Urquiza, Nora M. |
title |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
title_short |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
title_full |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
title_fullStr |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
title_full_unstemmed |
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
title_sort |
copper(ii) complexes of methimazole, an anti grave’s disease drug : synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor |
publishDate |
2009 |
url |
http://sedici.unlp.edu.ar/handle/10915/133155 |
work_keys_str_mv |
AT urquizanoram copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor AT mancasilviag copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor AT moyanomariaalejandra copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor AT dellmansraquelarrieta copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor AT lezamaluis copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor AT rojoteofilo copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor AT nasolucianagissella copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor AT williamspatriciaanamaria copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor AT ferrerevelinagloria copperiicomplexesofmethimazoleanantigravesdiseasedrugsynthesischaracterizationanditspotentialbiologicalbehaviorasalkalinephosphataseinhibitor |
bdutipo_str |
Repositorios |
_version_ |
1764820454907838464 |