Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor

Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<...

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Autores principales: Urquiza, Nora M., Manca, Silvia G., Moyano, María Alejandra, Dellmans, Raquel Arrieta, Lezama, Luis, Rojo, Teófilo, Naso, Luciana Gissella, Williams, Patricia Ana María, Ferrer, Evelina Gloria
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Química
Methimazole
Copper
Biometals
Grave’s disease
EPR
FTIR
UV-visible
ALP inhibition
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/133155
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-133155
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Methimazole
Copper
Biometals
Grave’s disease
EPR
FTIR
UV-visible
ALP inhibition
spellingShingle Química
Methimazole
Copper
Biometals
Grave’s disease
EPR
FTIR
UV-visible
ALP inhibition
Urquiza, Nora M.
Manca, Silvia G.
Moyano, María Alejandra
Dellmans, Raquel Arrieta
Lezama, Luis
Rojo, Teófilo
Naso, Luciana Gissella
Williams, Patricia Ana María
Ferrer, Evelina Gloria
Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
topic_facet Química
Methimazole
Copper
Biometals
Grave’s disease
EPR
FTIR
UV-visible
ALP inhibition
description Methimazole (MeimzH<b>)</b> is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)<sub>2</sub>(NO<sub>3</sub>)<sub>2</sub>].0.5H<sub>2</sub>O and [Cu(MeimzH)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.
format Articulo
Articulo
author Urquiza, Nora M.
Manca, Silvia G.
Moyano, María Alejandra
Dellmans, Raquel Arrieta
Lezama, Luis
Rojo, Teófilo
Naso, Luciana Gissella
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author_facet Urquiza, Nora M.
Manca, Silvia G.
Moyano, María Alejandra
Dellmans, Raquel Arrieta
Lezama, Luis
Rojo, Teófilo
Naso, Luciana Gissella
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author_sort Urquiza, Nora M.
title Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
title_short Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
title_full Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
title_fullStr Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
title_full_unstemmed Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
title_sort copper(ii) complexes of methimazole, an anti grave’s disease drug : synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/133155
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