Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype

The hypothalamic damage induced by neonatal treatment with monosodium l-glutamate (MSG) induces several metabolic abnormalities, resulting in a rat hyperleptinemic–hyperadipose phenotype. This study was conducted to explore the impact of the neonatal MSG treatment, in the adult (120 days old) female...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Perelló, Mario Carlos, Console-Avegliano, Gloria Miriam, Gaillard, Rolf C., Spinedi, Eduardo Julio
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Ciencias Médicas Hypothalamic obesity Hypophagia Mineralocorticoid Omental adiposity Glucocorticoid Leptin Insulin
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/132244
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-132244
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Hypothalamic obesity Hypophagia Mineralocorticoid Omental adiposity Glucocorticoid Leptin Insulin
spellingShingle	Ciencias Médicas Hypothalamic obesity Hypophagia Mineralocorticoid Omental adiposity Glucocorticoid Leptin Insulin Perelló, Mario Carlos Console-Avegliano, Gloria Miriam Gaillard, Rolf C. Spinedi, Eduardo Julio Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
topic_facet	Ciencias Médicas Hypothalamic obesity Hypophagia Mineralocorticoid Omental adiposity Glucocorticoid Leptin Insulin
description	The hypothalamic damage induced by neonatal treatment with monosodium l-glutamate (MSG) induces several metabolic abnormalities, resulting in a rat hyperleptinemic–hyperadipose phenotype. This study was conducted to explore the impact of the neonatal MSG treatment, in the adult (120 days old) female rat on: (a) the in vivo and in vitro mineralocorticoid responses to ACTH and angiotensin II (AII); (b) the effect of leptin on ACTH- and AII-stimulated mineralocorticoid secretions by isolated corticoadrenal cells; and (c) abdominal adiposity characteristics. Our data indicate that, compared with age-matched controls, MSG rats displayed: (1) enhanced and reduced mineralocorticoid responses to ACTH and AII treatments, respectively, effects observed in both in vivo and in vitro conditions; (2) adrenal refractoriness to the inhibitory effect of exogenous leptin on ACTH-stimulated aldosterone output by isolated adrenocortical cells; and (3) distorted omental adiposity morphology and function. This study supports that the adult hyperleptinemic MSG female rat is characterized by enhanced ACTH-driven mineralocorticoid function, impaired adrenal leptin sensitivity, and disrupted abdominal adiposity function. MSG rats could counteract undesirable effects of glucocorticoid excess, by developing a reduced AII-driven mineralocorticoid function. Thus, chronic hyperleptinemia could play a protective role against ACTH-mediated allostatic loads in the adrenal leptin resistant, MSG female rat phenotype.
format	Articulo Articulo
author	Perelló, Mario Carlos Console-Avegliano, Gloria Miriam Gaillard, Rolf C. Spinedi, Eduardo Julio
author_facet	Perelló, Mario Carlos Console-Avegliano, Gloria Miriam Gaillard, Rolf C. Spinedi, Eduardo Julio
author_sort	Perelló, Mario Carlos
title	Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_short	Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_full	Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_fullStr	Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_full_unstemmed	Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
title_sort	analysis of angiotensin ii- and acth-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/132244
work_keys_str_mv	AT perellomariocarlos analysisofangiotensiniiandacthdrivenmineralocorticoidfunctionsandomentaladiposityinanongenetichyperadiposefemaleratphenotype AT consoleaveglianogloriamiriam analysisofangiotensiniiandacthdrivenmineralocorticoidfunctionsandomentaladiposityinanongenetichyperadiposefemaleratphenotype AT gaillardrolfc analysisofangiotensiniiandacthdrivenmineralocorticoidfunctionsandomentaladiposityinanongenetichyperadiposefemaleratphenotype AT spinedieduardojulio analysisofangiotensiniiandacthdrivenmineralocorticoidfunctionsandomentaladiposityinanongenetichyperadiposefemaleratphenotype
bdutipo_str	Repositorios
_version_	1764820456144109568

Analysis of angiotensin II- and ACTH-driven mineralocorticoid functions and omental adiposity in a non-genetic, hyperadipose female rat phenotype

Ejemplares similares