Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress

Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspri...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Mónaco, Nina, Bartos, Mariana, Dominguez, Sergio, Gallegos, Cristina Eugenia, Bras, Cristina, del Carmen Esandi, María, Bouzat, Cecilia, Giannuzzi, Leda, Minetti, Alejandra, Gumilar, Fernanda
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Exactas
Química
Arsenic α7-nicotinic receptor
Oxidative stress
Glutamates
Female rats
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131976
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131976
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
Arsenic α7-nicotinic receptor
Oxidative stress
Glutamates
Female rats
spellingShingle Ciencias Exactas
Química
Arsenic α7-nicotinic receptor
Oxidative stress
Glutamates
Female rats
Mónaco, Nina
Bartos, Mariana
Dominguez, Sergio
Gallegos, Cristina Eugenia
Bras, Cristina
del Carmen Esandi, María
Bouzat, Cecilia
Giannuzzi, Leda
Minetti, Alejandra
Gumilar, Fernanda
Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
topic_facet Ciencias Exactas
Química
Arsenic α7-nicotinic receptor
Oxidative stress
Glutamates
Female rats
description Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of the exposure to low arsenite sodium levels through drinking water during pregnancy and lactation on short- and long-term memory. We also considered a possible underlying neurotoxic mechanism. Pregnant rats were exposed during pregnancy and lactation to environmentally relevant iAs concentrations (0.05 and 0.10 mg/L). In 90-day-old female offspring, short-term memory (STM) and long-term memory (LTM) were evaluated using a step-down inhibitory avoidance task. In addition, we evaluated the α7 nicotinic receptor (α7-nAChR) expression, the transaminases and the oxidative stress levels in hippocampus. The results showed that the exposure to 0.10 mg/L iAs in this critical period produced a significant impairment in the LTM retention. This behavioral alteration might be associated with several events that occur in the hippocampus: decrease in α7-nAChR expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (CAT) activity.
format Articulo
Articulo
author Mónaco, Nina
Bartos, Mariana
Dominguez, Sergio
Gallegos, Cristina Eugenia
Bras, Cristina
del Carmen Esandi, María
Bouzat, Cecilia
Giannuzzi, Leda
Minetti, Alejandra
Gumilar, Fernanda
author_facet Mónaco, Nina
Bartos, Mariana
Dominguez, Sergio
Gallegos, Cristina Eugenia
Bras, Cristina
del Carmen Esandi, María
Bouzat, Cecilia
Giannuzzi, Leda
Minetti, Alejandra
Gumilar, Fernanda
author_sort Mónaco, Nina
title Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_short Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_full Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_fullStr Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_full_unstemmed Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_sort low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : role of α7 nicotinic receptor, glutamate and oxidative stress
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/131976
work_keys_str_mv AT monaconina lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT bartosmariana lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT dominguezsergio lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT gallegoscristinaeugenia lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT brascristina lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT delcarmenesandimaria lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT bouzatcecilia lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT giannuzzileda lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT minettialejandra lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
AT gumilarfernanda lowarsenicconcentrationsimpairmemoryinratoffpringexposedduringpregnancyandlactationroleofa7nicotinicreceptorglutamateandoxidativestress
bdutipo_str Repositorios
_version_ 1764820453740773376

Ejemplares similares