Prostate cancer progression: as a matter of fats

Advanced prostate cancer (PCa) represents the fifth cause of cancer death worldwide. Although survival has improved with second-generation androgen signaling and Parp inhibitors, the benefits are not long-lasting, and new therapeutic approaches are sorely needed. Lipids and their metabolism have rec...

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Detalles Bibliográficos
Autores principales: Scaglia, Natalia, Frontini López, Yesica Romina, Zadra, Giorgia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
Llipid metabolism
Fatty acids
Prostate cancer
Castration resistance
Obesity
Microenvironment
Lipidomics
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131395
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131395
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Llipid metabolism
Fatty acids
Prostate cancer
Castration resistance
Obesity
Microenvironment
Lipidomics
spellingShingle Ciencias Médicas
Llipid metabolism
Fatty acids
Prostate cancer
Castration resistance
Obesity
Microenvironment
Lipidomics
Scaglia, Natalia
Frontini López, Yesica Romina
Zadra, Giorgia
Prostate cancer progression: as a matter of fats
topic_facet Ciencias Médicas
Llipid metabolism
Fatty acids
Prostate cancer
Castration resistance
Obesity
Microenvironment
Lipidomics
description Advanced prostate cancer (PCa) represents the fifth cause of cancer death worldwide. Although survival has improved with second-generation androgen signaling and Parp inhibitors, the benefits are not long-lasting, and new therapeutic approaches are sorely needed. Lipids and their metabolism have recently reached the spotlight with accumulating evidence for their role as promoters of PCa development, progression, and metastasis. As a result, interest in targeting enzymes/transporters involved in lipid metabolism is rapidly growing. Moreover, the use of lipogenic signatures to predict prognosis and resistance to therapy has been recently explored with promising results. Despite the well-known association between obesity with PCa lethality, the underlying mechanistic role of diet/obesity-derived metabolites has only lately been unveiled. Furthermore, the role of lipids as energy source, building blocks, and signaling molecules in cancer cells has now been revisited and expanded in the context of the tumor microenvironment (TME), which is heavily influenced by the external environment and nutrient availability. Here, we describe how lipids, their enzymes, transporters, and modulators can promote PCa development and progression, and we emphasize the role of lipids in shaping TME. In a therapeutic perspective, we describe the ongoing efforts in targeting lipogenic hubs. Finally, we highlight studies supporting dietary modulation in the adjuvant setting with the purpose of achieving greater efficacy of the standard of care and of synthetic lethality. PCa progression is "a matter of fats", and the more we understand about the role of lipids as key players in this process, the better we can develop approaches to counteract their tumor promoter activity while preserving their beneficial properties.
format Articulo
Articulo
author Scaglia, Natalia
Frontini López, Yesica Romina
Zadra, Giorgia
author_facet Scaglia, Natalia
Frontini López, Yesica Romina
Zadra, Giorgia
author_sort Scaglia, Natalia
title Prostate cancer progression: as a matter of fats
title_short Prostate cancer progression: as a matter of fats
title_full Prostate cancer progression: as a matter of fats
title_fullStr Prostate cancer progression: as a matter of fats
title_full_unstemmed Prostate cancer progression: as a matter of fats
title_sort prostate cancer progression: as a matter of fats
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/131395
work_keys_str_mv AT scaglianatalia prostatecancerprogressionasamatteroffats
AT frontinilopezyesicaromina prostatecancerprogressionasamatteroffats
AT zadragiorgia prostatecancerprogressionasamatteroffats
bdutipo_str Repositorios
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