Breast Cancer Risk and Prognostic Factors in Two Argentine Settings

Objectives: The purpose of this study was to compare risk and prognostic factors of invasive breast cancer in two Argentine populations. Patients and Methods: a total of 625 women with invasive breast cancer at different stages were studied: 270 patients from the city of La Plata, and 355 patients f...

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Detalles Bibliográficos
Autores principales: Demichelis, Sandra O., Cermignani, Luciano, Zwenger, Ariel Osvaldo, Giacomi, Nora, Barbera, Alberto, Segal-Eiras, Amada, Croce, María Virginia
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
Breast cancer
Risk factor
Prognostic factor
Socioeconomic status
Argentine setting
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131124
http://www.journalofcancerology.com/resumen.asp?id=38&indice=2015024
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131124
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Breast cancer
Risk factor
Prognostic factor
Socioeconomic status
Argentine setting
spellingShingle Ciencias Médicas
Breast cancer
Risk factor
Prognostic factor
Socioeconomic status
Argentine setting
Demichelis, Sandra O.
Cermignani, Luciano
Zwenger, Ariel Osvaldo
Giacomi, Nora
Barbera, Alberto
Segal-Eiras, Amada
Croce, María Virginia
Breast Cancer Risk and Prognostic Factors in Two Argentine Settings
topic_facet Ciencias Médicas
Breast cancer
Risk factor
Prognostic factor
Socioeconomic status
Argentine setting
description Objectives: The purpose of this study was to compare risk and prognostic factors of invasive breast cancer in two Argentine populations. Patients and Methods: a total of 625 women with invasive breast cancer at different stages were studied: 270 patients from the city of La Plata, and 355 patients from the city of Neuquén. Demographic features and reproductive history were considered as risk factors, while prognostic factors included histopathological features. Statistical analysis was performed. Results: The age at diagnosis was significantly lower in Neuquén than in La Plata; stage III was observed in La Plata at a mean age of 49 years versus 54 years in Neuquén; cutaneous and/or thoracic wall invasion was found at diagnosis in Neuquén, while it was absent in all La Plata patients. Tumor size versus age showed a negative statistical significant relationship; the percentage of HER2/neu-positives in Neuquén was significantly higher than in La Plata, while estrogen/progesterone receptor status showed the contrary. Histological and nuclear grades in Neuquén compared to La Plata were significantly higher, while vascular invasion showed the converse. Considering the number of children, significant differences between groups were found, and also, patients who had breastfed presented a lower number of metastatic lymph nodes than those who had not. Conclusions: La Plata and Neuquén constitute two different populations. The factors that contribute to dividing the groups could be related to the malignant histological characteristics of the tumors, but also the length of breastfeeding and number of children could play a role.
format Articulo
Preprint
author Demichelis, Sandra O.
Cermignani, Luciano
Zwenger, Ariel Osvaldo
Giacomi, Nora
Barbera, Alberto
Segal-Eiras, Amada
Croce, María Virginia
author_facet Demichelis, Sandra O.
Cermignani, Luciano
Zwenger, Ariel Osvaldo
Giacomi, Nora
Barbera, Alberto
Segal-Eiras, Amada
Croce, María Virginia
author_sort Demichelis, Sandra O.
title Breast Cancer Risk and Prognostic Factors in Two Argentine Settings
title_short Breast Cancer Risk and Prognostic Factors in Two Argentine Settings
title_full Breast Cancer Risk and Prognostic Factors in Two Argentine Settings
title_fullStr Breast Cancer Risk and Prognostic Factors in Two Argentine Settings
title_full_unstemmed Breast Cancer Risk and Prognostic Factors in Two Argentine Settings
title_sort breast cancer risk and prognostic factors in two argentine settings
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/131124
http://www.journalofcancerology.com/resumen.asp?id=38&indice=2015024
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