Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors
A controlled architecture of nanoelectrodes, of a similar size to small molecule-binding aptamers, is synthesized inside nanoporous alumina. Gold nanoparticles with a controlled size (about 2 nm) are electrogenerated in the alumina cavities, showing a fast electron transfer process toward ferrocyani...
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| Autores principales: | , , , , , , , |
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| Formato: | Articulo Preprint |
| Lenguaje: | Inglés |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/131123 |
| Aporte de: |
| id |
I19-R120-10915-131123 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Química Gold nanoparticles Detection of small molecules |
| spellingShingle |
Química Gold nanoparticles Detection of small molecules Peinetti, Ana S. Ceretti, Helena Mizrahi, Martín Daniel González, Graciela A. Ramírez, Silvana A. Requejo, Félix Gregorio Montserrat, Javier M. Battaglini, Fernando Confined gold nanoparticles enhance the detection of small molecules in label-free impedance aptasensors |
| topic_facet |
Química Gold nanoparticles Detection of small molecules |
| description |
A controlled architecture of nanoelectrodes, of a similar size to small molecule-binding aptamers, is synthesized inside nanoporous alumina. Gold nanoparticles with a controlled size (about 2 nm) are electrogenerated in the alumina cavities, showing a fast electron transfer process toward ferrocyanide. These uncapped nanoparticles are easily modified with a thiol-containing aptamer for label-free detection of adenosine monophosphate by electrochemical impedance spectroscopy. Our results show that the use of a limited electrical conducting surface inside an insulating environment can be very sensitive to conformational changes, introducing a new approach to the detection of small molecules, exemplified here by the direct and selective detection of adenosine monophosphate at the nanomolar scale. |
| format |
Articulo Preprint |
| author |
Peinetti, Ana S. Ceretti, Helena Mizrahi, Martín Daniel González, Graciela A. Ramírez, Silvana A. Requejo, Félix Gregorio Montserrat, Javier M. Battaglini, Fernando |
| author_facet |
Peinetti, Ana S. Ceretti, Helena Mizrahi, Martín Daniel González, Graciela A. Ramírez, Silvana A. Requejo, Félix Gregorio Montserrat, Javier M. Battaglini, Fernando |
| author_sort |
Peinetti, Ana S. |
| title |
Confined gold nanoparticles enhance the detection of small molecules in label-free
impedance aptasensors |
| title_short |
Confined gold nanoparticles enhance the detection of small molecules in label-free
impedance aptasensors |
| title_full |
Confined gold nanoparticles enhance the detection of small molecules in label-free
impedance aptasensors |
| title_fullStr |
Confined gold nanoparticles enhance the detection of small molecules in label-free
impedance aptasensors |
| title_full_unstemmed |
Confined gold nanoparticles enhance the detection of small molecules in label-free
impedance aptasensors |
| title_sort |
confined gold nanoparticles enhance the detection of small molecules in label-free
impedance aptasensors |
| publishDate |
2015 |
| url |
http://sedici.unlp.edu.ar/handle/10915/131123 |
| work_keys_str_mv |
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Repositorios |
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