Paradoxical effect of hypercapnia on toad heart muscle

Experiments were performed on strips dissected from toad ventricles driven at a constant frequency of 12 beats/min. After equilibration, the Pco2 of the medium was altered from 25 to 95 mm Hg or from 95 to 25 mm Hg. Developed tension (DT) and maximal rate of tension development (dT/dtmax) were recor...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Mattiazzi, Alicia Ramona, Cingolani, Horacio Eugenio
Formato: Articulo
Lenguaje:Inglés
Publicado: 1977
Materias:
Medicina
Ciencias Médicas
toad
hypocapnia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/131090
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-131090
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Ciencias Médicas
toad
hypocapnia
spellingShingle Medicina
Ciencias Médicas
toad
hypocapnia
Mattiazzi, Alicia Ramona
Cingolani, Horacio Eugenio
Paradoxical effect of hypercapnia on toad heart muscle
topic_facet Medicina
Ciencias Médicas
toad
hypocapnia
description Experiments were performed on strips dissected from toad ventricles driven at a constant frequency of 12 beats/min. After equilibration, the Pco2 of the medium was altered from 25 to 95 mm Hg or from 95 to 25 mm Hg. Developed tension (DT) and maximal rate of tension development (dT/dtmax) were recorded during a 30-minute period after the change in Pco2. In the first experimental series at 30°C, increasing Pco2, resulted in a decrease in DT and dT/dtmax, followed by a recovery of contractility that reached levels higher than controls. In the second and third series, performed after the addition to the bath of practolol (1 x 10-6M) or after reserpinization, high Pco2, depressed contractility but the recovery did not surpass control values after 30 minutes of hypercapnia. In this series, when high PcO2 was replaced by low Pco2 there was an increase in DT and dT/dtmax followed by a decrease that reached control levels within a 30-minute period. In the fourth series, at 22°C the significant decreases in DT and dT/dtmax observed after increasing Pco2 were followed by a recovery that surpassed control values. These results define the existence in toad cardiac muscle of a mechanism that tends to return contractility to control levels after a change in Pco2. Within 30 minutes this mechanism, present even after inhibition of catecholamine action, completely counteracts the primary negative inotropic effect of high Pco2 and the positive inotropic action of hypocapnia.
format Articulo
Articulo
author Mattiazzi, Alicia Ramona
Cingolani, Horacio Eugenio
author_facet Mattiazzi, Alicia Ramona
Cingolani, Horacio Eugenio
author_sort Mattiazzi, Alicia Ramona
title Paradoxical effect of hypercapnia on toad heart muscle
title_short Paradoxical effect of hypercapnia on toad heart muscle
title_full Paradoxical effect of hypercapnia on toad heart muscle
title_fullStr Paradoxical effect of hypercapnia on toad heart muscle
title_full_unstemmed Paradoxical effect of hypercapnia on toad heart muscle
title_sort paradoxical effect of hypercapnia on toad heart muscle
publishDate 1977
url http://sedici.unlp.edu.ar/handle/10915/131090
work_keys_str_mv AT mattiazzialiciaramona paradoxicaleffectofhypercapniaontoadheartmuscle
AT cingolanihoracioeugenio paradoxicaleffectofhypercapniaontoadheartmuscle
bdutipo_str Repositorios
_version_ 1764820453283594241

Ejemplares similares